918902-51-9

Basic information

• Product Name: L-Phenylalanine, N,1-bis[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-
• CAS NO: 918902-51-9
• Molecular Formula: C30H37N3O7
• Molecular Weight: 551.64
• Mol File: 918902-51-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, N,1-bis[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, N,1-bis[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-(918902-51-9)
• EPA Substance Registry System: L-Phenylalanine, N,1-bis[(1,1-dimethylethoxy)carbonyl]-L-tryptophyl-(918902-51-9)

Safety Data

• Hazardous Substances Data: 918902-51-9(Hazardous Substances Data)

Upstream product

• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 
• 144599-95-1 N^α-(tert-butoxycarbonyl)-1-methyl-L-tryptophan 
• 918902-48-4 Boc-Trp(Boc)-Phe-OMe 

Downstream Products

• 918902-56-4 C₃₀H₃₆N₃O₆(NHC₄H₅OO) 

Relevant articles and documents

Structure-activity studies of cyclic ketone inhibitors of the serine protease plasmin: Design, synthesis, and biological activity

Three series of cyclic ketone inhibitors were synthesized and evaluated against the serine protease plasmin. Peptide inhibitors that incorporated 3-oxotetrahydrofuran and 3-oxotetrahydrothiophene 1,1-dioxide groups had the highest activities. Alkylamino substituents, which were designed to bind in the S1 subsite of plasmin, were attached to the inhibitors. Compounds 5c and 5g, which incorporated 6-aminohexyl substituents, were found to be optimal and demonstrated IC50 values in the low micromolar range. Incorporating conformationally constrained peptide segments into the inhibitors did not improve their activities.