919079-41-7Relevant academic research and scientific papers
TMSCH2Li-induced regioselective lithiation of (S)-nicotine
Gros, Philippe C.,Doudouh, Abdelatif,Woltermann, Christopher
, p. 4331 - 4335 (2006)
The first regioselective C-4 lithiation of (S)-nicotine has been realized using TMSCH2Li as basic reagent in toluene. The reaction proceeded under mild conditions with a small excess of electrophile. The 4-chloro derivative was subsequently met
