91908-88-2 Usage
Chemical Structure
1-[(3,4-DIMETHOXYPHENYL)SULFONYL]PIPERAZINE is a chemical compound consisting of a piperazine ring with a sulfonamide attached to a 3,4-dimethoxyphenyl group.
Industry Use
It is commonly used in the pharmaceutical industry as a building block in the synthesis of various drugs.
Target
The drugs synthesized using 1-[(3,4-DIMETHOXYPHENYL)SULFONYL]PIPERAZINE are intended to act on the central nervous system.
Pharmacological Properties
It has been found to exhibit various pharmacological properties, including potential antipsychotic and antidepressant effects.
Research Interest
Due to its pharmacological properties, it is of interest for research purposes.
Potential Applications
It has been studied for its potential use in the treatment of inflammatory and neurological disorders.
Prodrug Potential
It has also been studied for its potential as a prodrug for targeted drug delivery.
Molecular Weight
The molecular weight is not provided in the material, but it can be calculated based on the atomic weights of the constituent atoms and the structure of the compound.
Physical Properties
The physical properties such as color, state, odor, solubility, etc., are not provided in the material.
Safety and Handling
Information regarding safety measures and handling procedures for 1-[(3,4-DIMETHOXYPHENYL)SULFONYL]PIPERAZINE is not provided in the material.
Regulatory Status
The regulatory status of 1-[(3,4-DIMETHOXYPHENYL)SULFONYL]PIPERAZINE, including any restrictions or guidelines for its use, is not provided in the material.
Synthesis
The method of synthesis for 1-[(3,4-DIMETHOXYPHENYL)SULFONYL]PIPERAZINE is not provided in the material.
Stability
Information regarding the stability of 1-[(3,4-DIMETHOXYPHENYL)SULFONYL]PIPERAZINE under different conditions is not provided in the material.
Reactivity
Information about the reactivity of 1-[(3,4-DIMETHOXYPHENYL)SULFONYL]PIPERAZINE with other substances is not provided in the material.
Toxicity
Information regarding the toxicity of 1-[(3,4-DIMETHOXYPHENYL)SULFONYL]PIPERAZINE is not provided in the material.
Environmental Impact
Information about the environmental impact of 1-[(3,4-DIMETHOXYPHENYL)SULFONYL]PIPERAZINE is not provided in the material.
Storage
Information regarding the storage conditions required for 1-[(3,4-DIMETHOXYPHENYL)SULFONYL]PIPERAZINE is not provided in the material.
Disposal
Information about the proper disposal methods for 1-[(3,4-DIMETHOXYPHENYL)SULFONYL]PIPERAZINE is not provided in the material.
Check Digit Verification of cas no
The CAS Registry Mumber 91908-88-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,1,9,0 and 8 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 91908-88:
(7*9)+(6*1)+(5*9)+(4*0)+(3*8)+(2*8)+(1*8)=162
162 % 10 = 2
So 91908-88-2 is a valid CAS Registry Number.
InChI:InChI=1/C12H18N2O4S/c1-17-11-4-3-10(9-12(11)18-2)19(15,16)14-7-5-13-6-8-14/h3-4,9,13H,5-8H2,1-2H3
91908-88-2Relevant academic research and scientific papers
Synthesis and biological evaluation of ethacrynic acid derivatives bearing sulfonamides as potent anti-cancer agents
Bignon, Jér?me,El Abbouchi, Abdelmoula,El Brahmi, Nabil,El Kazzouli, Sa?d,Guillaumet, Gérald,Hiebel, Marie-Aude,Suzenet, Franck
supporting information, (2020/08/07)
A series of ethacrynic acid (2-[2,3-dichloro-4-(2-methylidenebutanoyl)phenoxy]acetic acid) (EA, Edecrin) containing sulfonamides linked via three types of linkers namely 1,2-ethylenediamine, piperazine and 4-aminopiperidine was synthesized and subsequently evaluated in vitro against HL60 and HCT116 cancer cell lines. All the EA analogs, excluding 6a and 6c, showed anti-proliferative activity with IC50s in the micromolar range (less than 4 uM). Three derivatives 6b, 7b and 7e were selected for their interesting dual activity on HL60 cell line in order to be further evaluated against a panel of cancer cell lines (HCT116, A549, MCF7, PC3, U87-MG and SKOV3) as well as on MRC5 as a normal cell line. These compounds displayed IC50 values in nanomolar range against A549, MCF7, PC3 and HCT116 cell lines, deducing the discovery that piperazine or 4-aminopiperidine is the linker's best choice to develop EA analogs with highly potent anti-proliferative activities own up to 24 nM. Besides, in terms of selectivity, those linkers are more suitable offering safety ratios of up to 63.8.
Development of 2-amino-4-phenylthiazole analogues to disrupt myeloid differentiation factor 88 and prevent inflammatory responses in acute lung injury
Chen, Lingfeng,Chen, Hongjin,Chen, Pengqin,Zhang, Wenxin,Wu, Chao,Sun, Chuchu,Luo, Wu,Zheng, Lulu,Liu, Zhiguo,Liang, Guang
, p. 22 - 38 (2018/10/23)
Myeloid differentiation primary response protein 88 (MyD88), an essential adapter protein used by toll-like receptors (TLR), is a promising target molecule for the treatment of respiratory inflammatory diseases. Previous studies explored the activities of novel 2-amino-4-phenylthiazole analogue (6) in inflammation-induced cancer, and identified the analogue as an inhibitor of MyD88 toll/interleukin-1 receptor (TIR) homology domain dimerization. Here, we describe the synthesis of 47 new analogues by modifying different sites on this lead compound and assessed their anti-inflammatory activities in lipopolysaccharide-induced mouse primary peritoneal macrophages (MPMs). The most promising compound, 15d, was found to effectively interact with MyD88 protein and prevented formation of the MyD88 homodimeric complex. Furthermore, 15d showed in vivo anti-inflammatory activity in LPS-caused model of acute lung injury. This work provides new candidates as MyD88 inhibitors to combat inflammation diseases.
CHEMICAL COMPOUNDS
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Page/Page column 39, (2008/06/13)
The present invention relates generally to novel therapeutic compounds and AXOR 109 agonists, and processes for the manufacture and use of the same.
