919092-35-6Relevant academic research and scientific papers
A SAR study on a series of synthetic lipophilic chalcones as Inhibitor of transcription factor NF-κB
Venkateswararao, Eeda,Sharma, Vinay K.,Lee, Ki-Cheul,Sharma, Niti,Park, Sun-Hong,Kim, Youngsoo,Jung, Sang-Hun
, p. 379 - 386 (2012/10/08)
To define the structural features responsible for the activity of 2,4-dihydroxy-6-isopentyloxychalcone, a newly established inhibitor of LPS induced NF-κB activation (IC50 = 10 μM), a series of its analogues was prepared and studied for their i
Structural requirement of chalcones for the inhibitory activity of interleukin-5
Yang, Hyun-Mo,Shin, Hye-Rim,Cho, Soo-Hyun,Bang, Seong-Cheol,Song, Gyu-Yong,Ju, Jung-Hun,Kim, Mi-Kyeong,Lee, Seung-Ho,Ryu, Jae-Chun,Kim, Youngsoo,Jung, Sang-Hun
, p. 104 - 111 (2007/10/03)
Novel chalcones were found as potent inhibitors of interleukin (IL)-5. 1-(2-Benzyloxy-6-hydroxyphenyl)-3-(4-hydroxyphenyl)-2-propen-1-one (2b, 78.8% inhibition at 50 μM, IC50 = 25.3 μM) was initially identified as a potent inhibitor of IL-5. Th
