919103-45-0

Basic information

• Product Name: 6-Iodoxindole
• Synonyms: 6-Iodoxindole;6-Iodooxindole;1,3-Dihydro-6-iodo-2H-indol-2-one;6-Iodo-2-oxindole;6-Iodoindolin-2-one;6-iodo-1,3-dihydroindol-2-one
• CAS NO: 919103-45-0
• Molecular Formula: C₈H₆INO
• Molecular Weight: 259.041
• Mol File: 919103-45-0.mol

Chemical Properties

• Boiling Point: 365℃
• Flash Point: 174℃
• Appearance: /
• Density: 1.945
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-Iodoxindole(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Iodoxindole(919103-45-0)
• EPA Substance Registry System: 6-Iodoxindole(919103-45-0)

Safety Data

• Hazardous Substances Data: 919103-45-0(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
6-Iodoxindole is used as a precursor in organic synthesis for its high reactivity due to the presence of the iodine atom. This makes it useful in a variety of chemical reactions, contributing to the development of new compounds and materials.
Used in Pharmaceutical Applications:
6-Iodoxindole is used as a potential therapeutic agent in various diseases due to its potential biological activities. Its role in the synthesis of pharmaceuticals highlights its importance in the development of new drugs and treatments.
Used in Research and Development:
6-Iodoxindole is utilized in research and development for studying its potential applications in medicine and other fields. Its unique properties and reactivity make it a valuable tool for exploring new chemical pathways and understanding its interactions with biological systems.

Upstream product

• 99365-40-9 6-bromo-2,3-dihydro-1H-indole-2-one 
• 59-48-3 2-oxoindole 
• 88-73-3 2-Chloronitrobenzene 
• 1338507-93-9 diethyl 2-(4-iodo-2-nitrophen-1-yl)malonate 
• 1573120-04-3 dimethyl 2-(4-iodo-2-nitrophen-1-yl)malonate 
• 41252-95-3 1-chloro-4-iodo-2-nitrobenzene 

Downstream Products

• 919103-46-1 (2-Oxo-2,3-dihydro-1H-indol-6-ylsulfanyl)-benzoic acid 
• 919103-51-8 N-(2,5-Dimethyl-2H-pyrazol-3-yl)-2-(2-oxo-2,3-dihydro-1H-indol-6-ylsulfanyl)-benzamide 
• 1537909-08-2 3-[(4-dimethylaminomethyl-phenylamino)-phenyl-methylene]-6-iodo-1,3-dihydro-indol-2-one 
• 1535204-23-9 3-(hydroxy-phenyl-methylene)-6-iodo-1,3-dihydro-indol-2-one 
• 1535204-25-1 C₂₃H₂₀IN₃O*ClH 

Relevant articles and documents

Complementary Site-Selective Halogenation of Nitrogen-Containing (Hetero)Aromatics with Superacids

Site-selective functionalization of arenes that is complementary to classical aromatic substitution reactions remains a long-standing quest in organic synthesis. Exploiting the generation of halenium ion through oxidative process and the protonation of the nitrogen containing function in HF/SbF5, the chlorination and iodination of classically inert Csp2?H bonds of aromatic amines occurs. Furthermore, the superacid-promoted (poly)protonation of the molecules acts as a protection, favoring the late-stage selective halogenation of natural alkaloids and active pharmaceutical ingredients.

PROCESS FOR PREPARING 6-IODO-2-OXINDOLE

Disclosed is a method for the synthesis of 6-iodo-2-oxindole useful as intermediate in the manufacture of pharmaceutically active ingredients. Also disclosed is a novel intermediate used in the synthesis of this compound.

PROCESS FOR PREPARING 6-IODO-2-OXINDOLE

Disclosed is a method for the synthesis of 6-iodo-2-oxindole useful as intermediate in the manufacture of pharmaceutically active ingredients. Also disclosed is a novel intermediate used in the synthesis of this compound.

Kinase Inhibitors

The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.