41252-95-3

Usage

Uses

Used in Pharmaceutical Industry:
1-CHLORO-4-IODO-2-NITROBENZENE is used as a key intermediate in the synthesis of various pharmaceuticals. Its presence of multiple functional groups allows for the creation of a wide range of medicinal compounds, contributing to the development of new drugs and therapies.
Used in Dye Industry:
In the dye industry, 1-CHLORO-4-IODO-2-NITROBENZENE is utilized as a precursor for the production of dyes. Its halogenated and nitro groups enable the formation of diverse colorants, which are essential for various applications such as textiles, plastics, and printing inks.
Used in Organic Chemical Synthesis:
1-CHLORO-4-IODO-2-NITROBENZENE serves as a versatile intermediate in the synthesis of a variety of organic chemicals. Its unique structure allows for multiple reaction pathways, making it a valuable component in the production of specialty chemicals and complex molecules.
Used as a Reagent in Organic Reactions:
Due to its functional groups, 1-CHLORO-4-IODO-2-NITROBENZENE is employed as a reagent in various organic reactions. It plays a crucial role in the synthesis of complex molecules, facilitating the formation of desired products and enhancing the efficiency of chemical processes.

Upstream product

• 635-22-3 4-Chloro-3-nitroaniline 
• 610-41-3 3,4-dinitroaniline 
• 88-73-3 2-Chloronitrobenzene 
• 38818-50-7 4-chloro-3-nitro-benzoyl chloride 
• 637-87-6 1-Chloro-4-iodobenzene 
• 96-99-1 4-chloro-3-nitrobenzoate 
• 4771-47-5 3-chloro-2-nitro-benzoic acid 

Downstream Products

• 16604-98-1 2-chloro-5-iodoaniline 
• 130131-39-4 2-(4-Iodo-2-nitranilino)ethanol 
• 130131-33-8 (4-Iodo-2-nitro-phenyl)-(2-thiocyanato-ethyl)-amine 
• 130131-22-5 2-(2-Imino-thiazolidin-3-yl)-5-iodo-phenylamine; compound with ethanesulfonic acid 
• 16604-90-3 5-Iod-2-chlor-4'-hydroxy-azobenzol 
• 1038400-18-8 2-(4-chloro-3-nitrobenzyl)imidazo[1,2-a]pyridine 
• 1079437-51-6 C₁₆H₁₀ClN₃O₂S 
• 1196131-16-4 C₁₀H₁₃IN₂O₂ 
• 1190366-64-3 6-(4-chloro-3-nitrobenzyl)imidazo[2,1-b][1,3]thiazole 
• 1264686-74-9 2-(4-chloro-3-nitrobenzyl)imidazo[1,2-a]pyrimidine 
• 1331759-20-6 5,6-diphenyl-3-(4-chloro-3-nitrobenzyl)imidazo[2,1-b]thiazole 
• 1360598-04-4 4-iodo-2-nitro-1-(phenylsulfonyl)benzene 
• 1360598-05-5 3-nitro-4-phenylsulfonylbiphenyl 
• 1360598-06-6 4-(phenylsulfonyl)biphenyl-3-amine 

Relevant academic research and scientific papers

Pd-Catalyzed Decarboxylative Ortho-Halogenation of Aryl Carboxylic Acids with Sodium Halide NaX Using Carboxyl as a Traceless Directing Group

A highly regioselective Pd-catalyzed carboxyl directed decarboxylative ortho-C-H halogenation of cheap o-nitrobenzoic acids with NaX (X = I, Br) under aerobic conditions has been established. The utility of the method has been demonstrated by the gram-scale reaction and derivatization of the product. Experimental results have confirmed Pd and Bi played critical roles in the transformation and indicated the transformation might proceed via 2-halo-6-nitrobenzoic acid derivative intermediate.

Anthranilic diamides derivatives as potential ryanodine receptor modulators: Synthesis, biological evaluation and structure activity relationship

A series of novel anthranilic diamides derivatives (7a–s) containing halogen, trifluoromethyl group and cyano group were designed, synthesized, and characterized by melting point, 1H NMR, 13C NMR and elemental analyses. The bioactivity revealed that most of them showed moderate to excellent activities against oriental armyworm (Mythimna separata) and diamondback moth (Plutella xylostella). Above all, the larvicidal activity of 7o against oriental armyworm was 100% and 40% at 0.25 and 0.1 mg L?1, comparable to that of the standard chlorantraniliprole (100%, 0.25 mg L?1 and 20%, 0.1 mg L?1). What is more, 7o against diamondback moth displayed 90% insecticidal activity at 0.01 mg L?1, superior to chlorantraniliprole (45%, 0.01 mg L?1). The experiments 7o on the American cockroach (Periplaneta Americana) heart beating rates (Dorsal vessel) and contractile force were compared with chlorantraniliprole. In addition, 7o could affect the calcium homeostasis in the central neurons of the third larvae of oriental armyworm, which revealed that the ryanodine receptor is the potential target of 7o. The density functional theory (DFT) calculation results revealed the amide bridge, the benzene ring of anthraniloyl moiety and pyrazole ring might play an important role in the insecticidal activity through hydrophobic interactions and π-π conjugations.

Method for synthesizing m-iodonitrobenzene compound

Provided is a method for synthesizing m-iodonitrobenzene; in the presence of oxygen gas, a palladium catalyst, a copper additive, a bismuth reagent and potassium phosphate, an o-nitrobenzoic acid compound and metal iodide are subjected to a substitution reaction in an organic solvent to form a corresponding m-iodonitrobenzene compound, wherein a metal in the metal iodide is an alkali metal or an alkaline earth metal. The method has obvious advantages of cheap and easily obtained reaction raw materials (including o-nitrobenzoic acid and MI), small amount of the metal catalyst, minimum environmental pollution with oxygen gas as an oxidant, good tolerance on various functional groups on an aromatic ring and the like. The method can be widely applied in the fields of synthesis of drugs, materials, natural products and the like in industrial and academic circles.

PROCESS FOR PREPARING 6-IODO-2-OXINDOLE

Disclosed is a method for the synthesis of 6-iodo-2-oxindole useful as intermediate in the manufacture of pharmaceutically active ingredients. Also disclosed is a novel intermediate used in the synthesis of this compound.

PROCESS FOR PREPARING 6-IODO-2-OXINDOLE

Disclosed is a method for the synthesis of 6-iodo-2-oxindole useful as intermediate in the manufacture of pharmaceutically active ingredients. Also disclosed is a novel intermediate used in the synthesis of this compound.

Synthesis and potent antifungal activity against Candida species of some novel 1H-benzimidazoles

(Chemical Equation Presented) A series of 47 novel N1-alkylated- 2-aryl-5(6)-substituted-1H-benzimidazoles and their three novel indole analogues were synthesized and evaluated for in vitro antifungal activities against Candida species by the tube dilution method. The results showed that compounds 79 and 80, having pyridine at the position C-2, of benzimidazoles exhibited the greatest activity with MIC values of 6.25-3.12 μg/mL. Indole analogues 108-110 have no inhibitory activity.

THE INVENTION OF RADICAL REACTIONS. PART XVI. RADICAL DECARBOXYLATIVE BROMINATION AND IODINATION OF AROMATIC ACIDS

Thiohydroxamic esters of aromatic carboxylic acids undergo clean decarboxylative bromination or iodination on treatment with bromotrichloromethane, iodoform or diiodomethane in the presence of a radical initiator.