919113-01-2

Basic information

• Product Name: Butanamide, 2-[[[[(1R,2R)-2-(dimethylamino)cyclohexyl]amino]thioxomethyl]amino]-3, 3-dimethyl-N-(phenylmethyl)-, (2S)-
• CAS NO: 919113-01-2
• Molecular Formula: C22H36N4OS
• Molecular Weight: 404.62
• Mol File: 919113-01-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Butanamide, 2-[[[[(1R,2R)-2-(dimethylamino)cyclohexyl]amino]thioxomethyl]amino]-3, 3-dimethyl-N-(phenylmethyl)-, (2S)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanamide, 2-[[[[(1R,2R)-2-(dimethylamino)cyclohexyl]amino]thioxomethyl]amino]-3, 3-dimethyl-N-(phenylmethyl)-, (2S)-(919113-01-2)
• EPA Substance Registry System: Butanamide, 2-[[[[(1R,2R)-2-(dimethylamino)cyclohexyl]amino]thioxomethyl]amino]-3, 3-dimethyl-N-(phenylmethyl)-, (2S)-(919113-01-2)

Safety Data

• Hazardous Substances Data: 919113-01-2(Hazardous Substances Data)

Upstream product

• 479423-19-3 (2S)-N-benzyl-2-isothiocyanato-3,3-dimethylbutanamide 
• 320778-92-5 (1R,2R)-N,N-dimethylcyclohexane-1,2-diamine 
• 479423-20-6 N-((1R,2R)-2-NH₂-cyclohexyl)-N'-((S)-CH(t-Bu)CONHBn)thiourea 
• 50-00-0 formaldehyd 

Relevant articles and documents

Stereoselective nucleophilic addition to imines catalyzed by chiral bifunctional thiourea organocatalysts

A new and easy synthesis of chiral bifunctional organic catalysts obtained by the combination of (S)-t-leucine-derivatives with (1R,2R)-trans-1,2-diamino-cyclohexane was developed. A few compounds, representatives of a class of organocatalysts containing a thiourea group and a tertiary amino group connected through a chiral backbone, have been successfully synthesized. The catalytic behaviour of such bifunctional chiral molecules, either neutral or protonated species, was investigated in the addition of acetylacetone to β-nitrostyrene as a model reaction. Using the best conditions, high yields and enantioselectivities of up to 85% were obtained. The same metal free catalysts were then employed in the addition of activated nucleophiles to imines: in the reaction of 1,3-diketones with N-CBz imines, the products were isolated in up to 61% ee, while in the reaction with diethyl malonate enantioselectivities up to 71% were reached.