91914-05-5

Basic information

• Product Name: 2-HYDROXY-4-METHYL PYRIDINE
• Synonyms: 2-HYDROXY-4-METHYLPYRIDINE
• CAS NO: 91914-05-5
• Molecular Formula: C6H7NO
• Molecular Weight: 109.13
• Mol File: 91914-05-5.mol

Chemical Properties

• Melting Point: 128-133℃
• Boiling Point: 186℃(12 torr)
• Appearance: /
• Density: 1.120±0.06 g/cm3(Predicted)
• PKA: 10.62±0.10(Predicted)
• CAS DataBase Reference: 2-HYDROXY-4-METHYL PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-4-METHYL PYRIDINE(91914-05-5)
• EPA Substance Registry System: 2-HYDROXY-4-METHYL PYRIDINE(91914-05-5)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:
• Safety Statements: S26:; S37/39:
• Hazardous Substances Data: 91914-05-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Hydroxy-4-methyl pyridine is used as an intermediate in the synthesis of various pharmaceuticals for its versatile chemical properties, contributing to the development of new drugs and medications.
Used in Pesticide Industry:
2-HYDROXY-4-METHYL PYRIDINE is utilized as an intermediate in the production of pesticides, helping to create effective solutions for controlling pests and protecting crops.
Used as Antimicrobial Agent:
2-Hydroxy-4-methyl pyridine is used as an antifungal agent in agricultural applications, helping to prevent fungal infections in crops and maintain their health and yield.
Used in Industrial Applications:
2-HYDROXY-4-METHYL PYRIDINE is employed as an antimicrobial agent in various industrial settings to prevent the growth of microorganisms that could cause spoilage or damage to materials and products.

Upstream product

• 695-34-1 2-Amino-4-methylpyridine 
• 100848-70-2 2-methoxy-4-methyl-pyridine 
• 108-89-4 picoline 

Downstream Products

• 864684-80-0 ethyl 2-[(4-methylpyridin-2-yl)oxy]acetate 

Relevant articles and documents

Chemoselective Demethylation of Methoxypyridine

A chemoselective demethylation method for various methoxypyridine derivatives has been developed. Treatment of 4-methoxypyridine with L-selectride in THF for 2 h at reflux temperature afforded 4-hydroxypyridine in good yield; no reaction to anisole occurred. The utility of our method was demonstrated by the efficient synthesis of the metabolic substances of the antiulcer agent omeprazole. Chemoselective demethylation at the site of 3,5-dimethyl-4-methoxypyridine in the presence of 4-methoxybenzimidazole was achieved.

OXAZOLE AND THIAZOLE DERIVATIVES AS SELECTIVE PROTEIN KINASE INHIBITORS (C-KIT)

The present invention relates to compounds of formula I or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, A, Q, W and X are as defined in the description. These compounds selectively modulate, regulate, and/or inhibit signal transduction mediated by certain native and/or mutant proteine kinases implicated in a variety of human and animal diseases such as cell proliferative, metabolic, allergic, and degenerative disorders. More particularly, these compounds are potent and selective native and/or mutant c-kit inhibitors.

PROCESS FOR PRODUCTION OF 2-HYDROXY-4-SUBSTITUTED PYRIDINES

A process for preparing a 2-hydroxy-4-substituted pyridine compound using a microbiological method, a novel microorganism, and a novel compound are provided. According to the process, a function of a microorganism or a product obtained therefrom is exerted on a 4-substituted pyridine of the general formula (1): wherein R is a methyl group, a carboxyl group, a carbamoyl group, a hydroxyiminomethyl group or a cyano group, to obtain the corresponding 2-hydroxy-4-substituted pyridine compound. The novel microorganisms are the Delftia species YGK-A649 (FERM BP-10389), Delftia species YGK-C217 (FERM BP-10388), or Acidovorax species YGK-A854 (FERM BP-10387) and the novel compound is a 2-hydroxy-4-pyridinaldoxime.

Azetidinone compounds useful in the preparation of carbapenem antibiotics and process for preparing carbapenem and penem compounds

Compounds of formula (I): STR1 wherein: R1 is hydrogen or a hydroxy-protecting group; R2 is alkyl, alkoxy, halogen, optionally substituted phenyl or optionally substituted phenoxy; R3 is optionally substituted pyridyl, optionally substituted quinolyl or phenyl group which has a substituent of formula --CYNR5 R6, where Y is oxygen or sulfur, and R5 and R6 are each alkyl, aryl or aralkyl, or R5 and R6 and the nitrogen to which they are attached together form a heterocyclic group; is R4 hydrogen or an amino-protecting group; and Z is sulfur or oxygen; are valuable intermediates in the preparation of carbapenem compounds and retain a desirable configuration during conversion to such carbapenem compounds. Penem and carbapenem compounds having a group of formula --SA' are prepared from a corresponding compound having a substituted thio, sulfinyl or sulfonyl group at this position by reaction with a compound A'SH (where A' is an organic group) in the presence of a salt of a metal of Group II or III of the Periodic Table.