919283-66-2

Upstream product

• 870194-67-5 2-(2,4-bis-trifluoromethyl-phenoxy)-ethylamine 
• 870194-61-9 [3-chloro-4-(4-chlorocarbonyl-5-methyl-isoxazol-3-yl)-phenyl]-acetic acid methyl ester 
• 496856-44-1 methyl 2-(3-chloro-4-(triuoromethylsulfonyloxy)phenyl)acetate 
• 57017-95-5 methyl 3-chloro-4-hydroxyphenylacetate 
• 33697-81-3 (3-chloro-4-hydroxy-phenyl)-acetic acid 
• 870194-68-6 [2-(2,4-bis-trifluoromethyl-phenoxy)-ethyl]-carbamic acid tert-butyl ester 
• 870194-62-0 3-(2-chloro-4-methoxycarbonylmethyl-phenyl)-5-methyl-isoxazole-4-carboxylic acid tert-butyl ester 
• 870194-63-1 3-(2-chloro-4-methoxycarbonylmethyl-phenyl)-5-methyl-isoxazole-4-carboxylic acid 
• 908848-70-4 2,4-bis(trifluoromethyl)phenol 
• 870194-53-9 [3-chloro-4-(hydroxyimino-methyl)-phenyl]-acetic acid methyl ester 
• 496856-45-2 (3-chloro-4-cyanophenyl)acetic acid methyl ester 
• 870194-52-8 (3-chloro-4-formylphenyl)acetic acid methyl ester 

Relevant academic research and scientific papers

3,4,5-Trisubstituted isoxazoles as novel PPARδ agonists: Part 1

We report the identification of a novel series of trisubstituted isoxazoles as PPAR activators from a high-throughput screen. A series of structural optimizations led to improved efficacy and excellent functional receptor selectivity for PPARδ. The isoxazoles represent a series of agonists which display a scaffold that lies outside the typical PPAR agonist motif.