919366-33-9

Upstream product

• 620-08-6 4-methoxypyridine 
• 693-03-8 n-butyl magnesium bromide 
• 501-53-1 benzyl chloroformate 
• 109-69-3 n-Butyl chloride 

Downstream Products

• 919366-40-8 C₂₄H₂₅Cl₂NO₄ 
• 919366-44-2 2-butyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone 
• 919366-42-0 C₂₅H₂₇Cl₂NO₆S 

Relevant academic research and scientific papers

Catalytic enantioselective addition of dialkylzinc reagents to N-acylpyridinium salts

(Chemical equation presented) A pinch of salt: The first catalytic addition of dialkylzinc reagents to N-acylpyridinium salts with good yields and excellent enantioselectivities uses a copper-(S)-L complex as the catalyst. The versatility of the method is

4-Pyridone derivatives as new inhibitors of bacterial enoyl-ACP reductase FabI

Bacterial FAS provides essential fatty acids for use in the assembly of key cellular components. Among them, FabI is an enoyl-ACP reductase which catalyzes the final and rate-limiting step of bacterial FAS. It is a potential target for selective antibacterial action, because it shows low overall sequence homology with mammalian enzymes. Until today, various compounds have been reported as inhibitors of bacterial FabI-inhibitory compounds. To discover novel small-molecular FabI inhibitors, we initially screened our compound library for inhibitory activity toward FabI of Escherichia coli. And discovered 4-pyridone derivatives as a lead compound. Structure optimization studies yielded 4-pyridone derivatives 7n having strong FabI-inhibitory and antibacterial activities against Staphylococcus aureus. There have been no reports concerning 4-pyridone derivatives as FabI inhibitor.