BENZYL 2-N-BUTYL-4-OXO-3,4-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE

Base Information

• Chemical Name: BENZYL 2-N-BUTYL-4-OXO-3,4-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE
• CAS No.: 919366-33-9
• Molecular Formula: C17H21NO3
• Molecular Weight: 287.35400
• Mol file: 919366-33-9.mol

Synonyms:BENZYL 2-N-BUTYL-4-OXO-3,4-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE;1-benzyloxycarbonyl-2-butyl-2,3-dihydro-4-pyridone;

Chemical Property of BENZYL 2-N-BUTYL-4-OXO-3,4-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE

Chemical Property:

• PSA: 46.61000
• LogP: 3.60840

Purity/Quality:

98% ^*data from raw suppliers

Benzyl2-n-butyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZYL 2-N-BUTYL-4-OXO-3,4-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE

There total 2 articles about BENZYL 2-N-BUTYL-4-OXO-3,4-DIHYDROPYRIDINE-1(2H)-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methoxypyridine (620-08-6,1232006-56-2) + n-butyl magnesium bromide (693-03-8) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl 2-butyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate (919366-33-9)

Guidance literature:

4-methoxypyridine; n-butyl magnesium bromide; benzyl chloroformate; In tetrahydrofuran;

With hydrogenchloride; at 20 ℃; for 0.166667h; Further stages.;

DOI:10.1016/j.bmc.2006.10.012

Reference yield:

4-methoxypyridine (620-08-6,1232006-56-2) + n-Butyl chloride (109-69-3) + benzyl chloroformate (501-53-1,94274-21-2) → benzyl 2-butyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate (919366-33-9)

Guidance literature:

n-Butyl chloride; With magnesium; In diethyl ether; Inert atmosphere;

4-methoxypyridine; benzyl chloroformate; With copper(l) chloride; In tetrahydrofuran; diethyl ether; at 0 ℃; Inert atmosphere;

DOI:10.1002/anie.200904981

Reference yield:

benzyl 2-butyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate (919366-33-9) + 2,6-dichlorobenzaldehyde (83-38-5) → C24H25Cl2NO4 (919366-40-8)

Guidance literature:

benzyl 2-butyl-4-oxo-3,4-dihydropyridine-1(2H)-carboxylate; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃;

2,6-dichlorobenzaldehyde; In tetrahydrofuran; at -78 ℃; for 1h; Further stages.;

DOI:10.1016/j.bmc.2006.10.012

upstream raw materials:

4-methoxypyridine

n-butyl magnesium bromide

benzyl chloroformate

n-Butyl chloride

Downstream raw materials:

C₂₄H₂₅Cl₂NO₄

2-butyl-3-(2,6-dichlorobenzyl)-2-methyl-4-pyridone

C₂₅H₂₇Cl₂NO₆S