91941-11-6

Basic information

• Product Name: Benzenesulfonamide, 4-[[(6-amino-5-nitro-2-pyridinyl)amino]methyl]-
• CAS NO: 91941-11-6
• Molecular Formula: C12H13N5O4S
• Molecular Weight: 323.332
• Mol File: 91941-11-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, 4-[[(6-amino-5-nitro-2-pyridinyl)amino]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, 4-[[(6-amino-5-nitro-2-pyridinyl)amino]methyl]-(91941-11-6)
• EPA Substance Registry System: Benzenesulfonamide, 4-[[(6-amino-5-nitro-2-pyridinyl)amino]methyl]-(91941-11-6)

Safety Data

• Hazardous Substances Data: 91941-11-6(Hazardous Substances Data)

Upstream product

• 138-39-6 4-homosulfanilamide 
• 27048-04-0 2-amino-6-chloro-3-nitropyridine 
• 16013-85-7 2,6-dicholoro-3-nitropyridine 

Downstream Products

• 1027952-87-9 4-[(5,6-Diamino-pyridin-2-ylamino)-methyl]-benzenesulfonamide 

Relevant articles and documents

Synthesis and quantitative structure-activity relationships of anticonvulsant 2,3,6-triaminopyridines

The synthesis of 2,3,6-triaminopyridine derivatives, representing a unique chemical structure for anticonvulsants, is described. The synthetic program was performed (a) to identify more potent analogs, (b) to determine structural properties controlling potency as well as neurotoxicity, and (c) to reduce the requirements for animal testing. As a result, besides other structural properties, the overall molecular lipophilicity (log k', octanol- coated column) explained changes in anticonvulsant potency and neurotoxicity. Mimicking the interaction of the amphiphilic triaminopyridines with biological membranes, NMR experiments in the presence of lecithin vesicles were conducted in order to measure the phospholipid-binding parameter log Δ(1/T2). Replacement of log k' with log Δ(1/T2) in the correlation analysis afforded a more significant equation describing the anticonvulsant activity of 21 derivatives.