91958-67-7

Basic information

• Product Name: 1-[(benzyloxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid
• Synonyms: 1-[(benzyloxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid;WWVCWLBEARZMAH-UHFFFAOYSA-N
• CAS NO: 91958-67-7
• Molecular Formula: C₁₃H₁₅NO₅
• Molecular Weight: 265.2619
• Mol File: 91958-67-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-[(benzyloxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(benzyloxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid(91958-67-7)
• EPA Substance Registry System: 1-[(benzyloxy)carbonyl]-4-hydroxypyrrolidine-2-carboxylic acid(91958-67-7)

Safety Data

• Hazardous Substances Data: 91958-67-7(Hazardous Substances Data)

Usage

Type of compound

Organic compound

Derivative of

Pyrrolidine

Industry use

Pharmaceutical industry

Purpose

Building block for the synthesis of peptides and other organic molecules

Functional groups

Carboxylic acid group, hydroxyl group

Versatility

Facilitates chemical reactions and synthesis

Additional groups

Benzyloxy and carbonyl groups

Reactivity and stability

Contribute to reactivity and stability in various chemical processes

Importance

Medicinal chemistry and drug development

Role

Precursor in the synthesis of biologically active molecules

Upstream product

• 108-91-8 cyclohexylamine 
• 64187-47-9 1-benzyloxycarbonyl-4-keto-L-proline 
• 36901-86-7 cis-hydroxy-D-proline 
• 501-53-1 benzyl chloroformate 
• 51-35-4 4-hydroxyproline 

Downstream Products

• 876624-27-0 4-hydroxy-2-(1,2,3,4-tetrahydro-naphthalen-1-ylcarbamoyl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 1196883-16-5 (2R,4R)-2-(4-Cyclobutyl-[1,4]diazepane-1-carbonyl)-4-hydroxy-pyrrolidine-1-carboxylic acid benzyl ester 
• 96167-96-3 Z-L-Hyp(tBu)-OtBu 
• 119071-05-5 Z-L-Val-L-Hyp(tBu)-OtBu 
• 93527-54-9 H-L-Hyp(tBu)-OtBu 
• 92246-88-3 N-carbobenzyloxy-trans-4-hydroxy-L-proline methyl ester 
• 95656-88-5 benzyl 3-hydroxypyrrolidine-1-carboxylate 

Relevant articles and documents

SUBSTITUTED PYRROLIDINE AMIDES AS MODULATORS OF THE HISTAMINE H3 RECEPTOR

Certain substituted pyrrolidine amide compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.

Heterocyclic benzenesulphonamide compounds as bradykinine antagonists

The invention concerns compounds selected among the group consisting of (i) compounds of formula (I) wherein: Het1 represents a nitrogenous heterocycle with 5 apices, in particular imidazole, pyrazole, or triazole; Het2 represents a nitrogenous heterocycle with 4, 5 or 6 apices, selected among the heterocycles: (II) wherein R1and R2are defined as mentioned in the description; and (ii) their additive salts. The invention also concerns the method for preparing said compounds and their use in therapy, in particular for treating pathologies involving bradykinine.

Aromatic amidine derivatives useful as selective thrombin inhibitors

The present invention relates to a novel thrombin inhibitor which is effective even when orally administered. More specifically, the present invention relates to an aromatic amidine derivative represented by formula (I) and the salts thereof, which show potent selective inhibitory activity for thrombin in which (a), R, R1, R2, R3, A, W, Y and n are defined as described in the specification.

Boronic ester and acid compounds, synthesis and uses

Disclosed herein are boronic ester and acid compounds, their synthesis and uses. More specifically, disclosed herein is a method for reducing the rate of degradation of proteins in an animal comprising contacting cells of the animal with certain boronic ester and acid compounds.

Method of inhibiting the transport of L-glutamate to treat CNS disorders

A method of inhibiting the transport of a neurotransmitter away from the synapse comprising contacting a neurotransmitter transporter with a compound having the structure STR1 wherein STR2 or CONHR 3 in any combination and and wherein R 2 =OR 3, NR 3 2, alkyl, or substituted alkyl and R 3 =alkyl or substituted alkyl.

BORONIC ESTER AND ACID COMPOUNDS

Disclosed herein is a method for reducing the rate of degradation of proteins in an animal comprising contacting cells of the animal with certain boronic ester and acid compounds. Also disclosed herein are novel boronic ester and acid compounds, their synthesis and uses.

MERCAPTOACYL DERIVATIVES OF SUBSTITUTED PROLINES

New mercaptoacyl derivatives of substituted prolines which have the general formula STR1 are useful as hypotensive agents.

Carbamate derivatives of mercaptoacyl hydroxy prolines

New carbamate derivatives of mercaptoacyl hydroxy prolines which have the general formula STR1 are useful as hypotensive agents.