91971-58-3

Upstream product

• 91-16-7 1,2-dimethoxybenzene 
• 541-41-3 chloroformic acid ethyl ester 
• 64-17-5 ethanol 
• 1521-38-6 2,3-dimethoxybenzoic acid 

Downstream Products

• 93213-66-2 3-Phenyl-1-(2,3-dimethoxy-phenyl)-propandion-(1,3) 
• 176901-48-7 ethyl 5-bromo-2,3-dimethoxybenzoate 
• 77298-64-7 8-hydroxyflavone 
• 101002-47-5 (4-oxo-2-phenyl-4H-1-benzopyran-8-yl)oxy acetic acid 
• 101002-53-3 (4-Oxo-2-phenyl-4H-chromen-8-yloxy)-acetic acid ethyl ester 
• 101018-55-7 (4-Oxo-2-phenyl-4H-chromen-8-yloxy)-acetic acid 2-morpholin-4-yl-ethyl ester; hydrochloride 
• 1448801-19-1 (S)-2-((Z)-5-(4-((E)-(2-(2,3-dimethoxybenzoyl)hydrazono)methyl)benzylidene)-4-oxo-2-thioxothiazolidin-3-yl)-3-phenylpropanoic acid 
• 35030-98-9 ethyl 2-hydroxy-3-methoxybenzoate 
• 181016-76-2 6-[2-(2-Bromomethyl-5-isopropyl-3,4-dimethoxy-phenyl)-ethyl]-7,7-dimethyl-1,4-dioxa-spiro[4.5]decane 
• 181016-83-1 {6-[2-(7,7-Dimethyl-1,4-dioxa-spiro[4.5]dec-6-yl)-ethyl]-4-isopropyl-2,3-dimethoxy-phenyl}-methanol 
• 176901-52-3 6-[2-(3-Isopropyl-4,5-dimethoxy-phenyl)-ethyl]-7,7-dimethyl-1,4-dioxa-spiro[4.5]decane 
• 176901-51-2 2-[2-(3-isopropyl-4,5-dimethoxyphenyl)ethyl]-5,5-dimethyl-cyclohexan-1-one 
• 181016-82-0 5-[2-(3-isopropyl-4,5-dimethoxyphenyl)ethyl]-5,5-dimethyl-2-cyclohexen-1-one 
• 181016-77-3 2‐(5‐bromo‐2,3‐dimethoxyphenyl)propan‐2‐ol 

Relevant academic research and scientific papers

Design, synthesis, pharmacological evaluation and molecular docking studies of substituted oxadiazolyl-2-oxoindolinylidene propane hydrazide derivatives

The manuscript describes design and synthesis of novel oxadiazolyl-2-oxoindolinylidene propane hydrazides as amide tethered hybrids of indole and oxadiazole and their evaluation for antiinflammatory and analgesic activity. The compounds were synthesized following five step reaction to yield fifteen derivatives as 3-(5-substituted-1,3,4-oxadiazol-2-yl)-N′-[2-oxo-1,2-dihydro-3Hindol-3-ylidene]propane hydrazides. The final derivatives 3-[5-(4-hydroxyphenyl)-1,3,4-oxadiazol-2-yl]-N′-[2-oxo-1,2-dihydro-3H-indol-3-ylidene]propane hydrazide and 3-[5-(4-methylphenyl)-1,3,4-oxadiazol-2-yl]-N′-[2-oxo-1,2-dihydro-3H-indol-3-ylidene]propane hydrazide were found to be highly promising molecules with severity index of 0.35 and 0.56, respectively, which is promising for an analgesic compound. The hydroxy and methyl substitution on phenyl ring system provided with active anti-inflammatory compounds having increase in reaction time of 84.11 and 83.17percent, respectively compared to standard drug at 85.84percent. Molecular docking studies exhibit comparable interaction with synthesized derivatives and standard drug having a dock score of -4.44 by the K-nearest neighbour genetic algorithm method.

Novel arylhydrazone derivatives bearing a rhodanine moiety: Synthesis and evaluation of their antibacterial activities

A series of arylhydrazone derivatives bearing a rhodanine moiety have been synthesized, characterized, and evaluated as antibacterial agents. Some of these compounds showed potent antibacterial activities against several different strains of Gram-positive bacteria, including multidrug-resistant clinical isolates. Of the compounds tested, IIk and IIIk were identified as the most effective, with minimum inhibitory concentration values of 2-4 μg/mL against multidrug-resistant Gram-positive organisms, including methicillin-resistant and quinolone-resistant Staphylococcus aureus. None of the compounds exhibited any activity against the Gram-negative bacteria Escherichia coli 1356 at 64 μg/mL.

The first total synthesis of (±)-demethyl salvicanol

Demethyl salvicanol, a novel rearranged 9(10 → 20)-abeo-8, 11, 13-triene diterpene, has been synthesized for the first time. The zinc-promoted coupling reaction of benzyl bromide with ketone and the alkylation of ketone with iodide are the key steps.