91973-38-5

Upstream product

• 92290-75-0 2-chloro-6-phenyl-isonicotinic acid ethyl ester 
• 77287-34-4 formamide 
• 121775-04-0 1-Amino-2-phenyl-pyridinium 
• 1045325-76-5 2-chloro-6-phenylisonicotinoyl chloride 
• 92199-59-2 ethyl 2-phenylpyridine-4-carboxylate 

Downstream Products

• 96982-28-4 2-phenyl-thioisonicotinic acid amide 
• 33744-17-1 2-phenylpyridine-4-carbonitrile 

Relevant academic research and scientific papers

Site-selective direct C-H pyridylation of unactivated alkanes by triplet excited anthraquinone

Site-selective C-H functionalization in chemical feedstocks is a challenging and useful reaction in the broad field of chemical research. Here, we report a modular photochemical platform for the site-selective C-H pyridylation of unactivated hydrocarbons via the unique synergistic effects of triplet excited anthraquinone and an amidyl radical-based reverse hydrogen atom transfer (RHAT) agent. The selective pyridylation of tertiary and secondary C(sp3)-H bonds in abundant chemical feedstocks was achieved by employing various N-aminopyridinium salts in a highly selective fashion, thus providing a new catalytic system for the direct construction of high-value-added compounds under ambient reaction conditions. Moreover, this operationally simple protocol is applicable to a variety of linear-, branched-, and cyclo-alkanes and more complex molecules with high degrees of site selectivity under visible-light conditions, which provides rapid and straightforward access to versatile synthons for upgrading feedstocks under mild, metal-free reaction conditions.