919802-68-9Relevant academic research and scientific papers
A Pd(0) based cross-coupling approach to the synthesis of 2-amidopurines and their evaluation as CDK inhibitors
Vandromme, Lucie,Legraverend, Michel,Kreimerman, Sergio,Lozach, Olivier,Meijer, Laurent,Grierson, David S.
, p. 130 - 141 (2007/10/03)
Two new series of 2-amido- and 2-aminocarbonylpurines have been synthesized using a Pd catalyst cross-coupling reaction either with amides or amines in the presence of CO. Moderate in vitro inhibitory activity against CDK1 and CDK5 was observed with ICsu
