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Usage

Uses

Used in Pharmaceutical Synthesis:
2-(p-tolyl)phthalazin-1(2H)-one is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new medicinal compounds.
Used in Organic Chemistry Research:
In the field of organic chemistry, 2-(p-tolyl)phthalazin-1(2H)-one is used as a research compound to explore its unique structure and reactivity, potentially leading to advancements in organic synthesis and compound design.
Used in Drug Discovery and Development:
2-(p-tolyl)phthalazin-1(2H)-one is utilized as a building block in drug discovery and development processes, where its chemical properties and structure play a crucial role in creating a wide range of organic compounds with potential therapeutic applications.
Used in Organic Compound Production:
2-(p-tolyl)phthalazin-1(2H)-one is employed as an important intermediate in the production of various organic compounds, highlighting its versatility and significance in the synthesis of a broad spectrum of chemical entities.

Upstream product

• 113386-47-3 2-p-Tolyl-1,2-dihydro-phthalazin-1-ol 
• 113386-57-5 2-[(4-Methoxy-phenyl)-hydrazonomethyl]-benzaldehyde 
• 201230-82-2 carbon monoxide 
• 19820-56-5 2-formylphenyl tosylate 
• 637-60-5 p-tolylhydrazine hydrochloride 
• 90-02-8 salicylaldehyde 
• 539-44-6 N-4-methylphenylhydrazine 
• 119-67-5 o-carboxybenzaldehyde 
• 50-00-0 formaldehyd 
• 610-94-6 2-bromobenzoic acid methyl ester 
• 15226-74-1 dicobalt octacarbonyl 
• 6630-33-7 ortho-bromobenzaldehyde 
• 113386-58-6 2-(p-Tolyl-hydrazonomethyl)-benzaldehyde 
• 113386-46-2 1-hydroxy-2-(p-methoxyphenyl)-1,2-dihydrophthalazine 

Relevant academic research and scientific papers

Preparation method of substituted 2, 3-phthalazinone compound

The invention provides a preparation method of a substituted 2, 3-phthalazinone compound. The method includes the steps of: (1) adding substituted hydrazine and substituted o-carboxybenzaldehyde intoa reaction container, controlling the reaction temperature at 50DEG C-150DEG C, and carrying out thermal insulation reaction under mechanical mixing; and (2) carrying out TLC or gas phase monitoring reaction, at the end of the reaction, adding a precipitating agent into the reaction system, conducting stirring for 0.5-1.0h, and conducting standing and filtering to obtain a solid crystal, i.e. thesubstituted 2, 3-phthalazinone compound. Starting from cheap and easily available raw materials, the preparation method provided by the invention employs one-pot process for efficient preparation of aseries of highly bioactive substituted 2, 3-phthalazinone compounds with a yield of 90%-99% under a molten state. The method has the characteristics of wide substrate application range, no adding ofcatalyst, no use of solvent and mild conditions, the reaction time is shortened by 95% or more than that of the catalytic preparation method under the traditional solvent condition, and the product purity is very high.

Access to phthalazinones via palladium-catalyzed three-component cycloamino-carbonylation of 2-formylaryl tosylates, hydrazines and CO

The palladium-catalyzed three-component cycloaminocarbonylation of 2-formylaryl tosylates with hydrazines and carbon monoxide has been established, which provides an efficient method for synthesis of substituted phthalazinones. In addition, by applying this protocol as the key step, Hydralazine can easily be synthesized in 65% yield.

Convenient method for the synthesis of phthalazinones via carbonylation of 2-bromobenzaldehyde using Co2(CO)8 as a CO source

A simple one-pot synthesis of phthalazinones by the condensation and intra-molecular carbonylative cyclization of 2-bromobenzaldehydes with hydrazines is reported. This method utilizes solid Co2(CO) 8 as carbonyl source making it rea

Palladium-catalyzed phthalazinone synthesis using paraformaldehyde as carbon source

A palladium-catalyzed one-pot synthesis of phthalazinones from 2-halomethyl benzoates, paraformaldehyde, and aryl hydrazines is described. Various substituted phthalazinones were selectively obtained in good yields using paraformaldehyde as the cheap carbon source (CH). (Chemical Equation Presented).

Palladium-catalyzed synthesis of phthalazinones: Efficient carbonylative coupling of 2-bromobenzaldehydes and hydrazines

Phthalazinones made easy! A new, straightforward methodology for the carbonylative synthesis of phthalazinones has been established. Starting from readily available 2-bromobenzaldehydes or 2-bromoacetophenone and hydrazines, a variety of phthalazinones have been produced in good isolated yields (see scheme). Copyright

A trans-Folded Alkene System: Synthesis, Structure and Isomerization of 2,2'-Diaryl-1,1'-bi(1,2-dihydrophthalazinylidenes)

A series of 2,2'-diaryl-1,1'-bi(1,2-dihydrophthalazinylidenes) have been synthesized from 1-hydroxy-2-aryl-1,2-dihydrophthalazines.An X-ray crystal structure showed relief of strain in these new ylidenes by a trans-folding of the alkene linkage.The mechanism of their formation was probed with additives such as sulphur, N-phenylmaleimide, and dimethyl acetylenedicarboxylate which interacted with intermediates in the reaction and gave further interesting new ylidene structures.The mechanism of trans-cis isomerization of the biphthalazinylidenes was studied using 270 MHz 1 H-NMR spectroscopy to measure the kinetics and activation parameters for the isomerization.X-Ray crystal structures of the following compounds are reported: 2,2'(p-bromophenyl)-trans-1,1'-bi--4--1-phenyl-3,4-dihydropyrrole-2,5-dione, (10d); dimethyl 3-(2-phenyl-1,2-dihydrophthalazin-1-ylidene)-2-oxobutanedioate (11), and dimethyl 2-acetoxy-3-(2-phenyl-1,2-dihydrophthalazin-1-yl)but-2-ene-1,4-dioate (12).