91990-88-4

Usage

Uses

Used in Research Applications:
4-Benzoylbenzoic acid succinimidyl ester is used as a research tool for investigating protein-protein interactions and other biological processes. Its photoreactive properties enable the study of these interactions under controlled conditions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-benzoylbenzoic acid succinimidyl ester is used as a heterobifunctional crosslinking agent for drug development. Its ability to react with amines and undergo non-specific reactions upon photoirradiation makes it a valuable tool for the synthesis of novel drug candidates and the modification of existing ones.
Used in Bioconjugation:
4-Benzoylbenzoic acid succinimidyl ester is used as a bioconjugation agent to attach biologically active molecules, such as peptides, proteins, or nucleic acids, to various surfaces or other molecules. This allows for the development of new diagnostic tools, sensors, and therapeutic agents.
Used in Materials Science:
In materials science, 4-benzoylbenzoic acid succinimidyl ester is used as a crosslinking agent to modify the properties of polymers and other materials. Its ability to react with amines and undergo photoirradiation-induced crosslinking enables the development of new materials with tailored properties for various applications.

InChI:InChI=1/C18H13NO5/c20-15-10-11-16(21)19(15)24-18(23)14-8-6-13(7-9-14)17(22)12-4-2-1-3-5-12/h1-9H,10-11H2

Upstream product

• 6066-82-6 1-hydroxy-pyrrolidine-2,5-dione 
• 611-95-0 4-carboxybenzophenone 

Downstream Products

• 165898-24-8 N^α-(4-benzoylbenzoyl)-L-biocytin 
• 929681-73-2 N-(4-benzoylbenzoyl)-S-tritylglutathione 
• 334616-64-7 (S)-6-tert-butoxycarbonyl-2-(4-benzoylbenzoylamino)hexanoic acid 
• 165898-25-9 1-(N-(N^α-(4-benzoylbenzoyl)-L-biocytinoyl)amino)-6-(N'-boc-amino)hexane 

Relevant academic research and scientific papers

High-throughput multiplexed competitive immunoassay for pollutants sensing in water

The present study described the development and evaluation of a new fully automated multiplex competitive immunoassay enabling the simultaneous detection of five water pollutants (okadaic acid (OA), 2-chloro-4-ethylamino-6- isopropylamino-1,3,5-triazine (atrazine), 2.4-dichlorophenoxyacetic acid (2,4-D), 2,4,6-trinitrotoluene (TNT), and 1,3,5-trinitroperhydro-1,3,5-triazine (RDX)). The technology is taking advantage of an optical-clear pressure-sensitive adhesive on which biomolecules can be immobilized and that can be integrated within a classical 96-well format. The optimization of the microarray composition and cross-reaction was performed using an original approach where probe molecules (haptens) were conjugated to different carriers such as protein (bovine serum albumin or ovalbumin), amino-functionalized latex beads, or dextran polymer and arrayed at the surface of the adhesive. A total of 17 different probes were then arrayed together with controls on the adhesive surface and screened toward their specific reactivity and cross-reactivity. Once optimized, the complete setup was used for the detection of the five target molecules (less than 3 h for 96 samples). Limits of detection of 0.02, 0.01, 0.01, 100, and 0.02 μg L-1 were found for OA, atrazine, 2,4-D, TNT, and RDX, respectively. The proof of concept of the multiplex competitive detection (semiquantitative or qualitative) of the five pollutants was also demonstrated on 16 spiked samples.

PHOTOPROXIMITY PROFILING OF PROTEIN-PROTEIN INTERACTIONS IN CELLS

Photoactive probes and probe systems for detecting biological interactions are described. The photoactive probes include probes that combine both photocleavable and photoreactive moieties. The photoactive probe systems can include a first probe comprising a photocatalytic group and a second probe comprising a group that can act as a substrate for the reaction catalyzed by the photocatalytic group. The probes and probe systems can also include groups that can specifically bind to a binding partner on a biological entity of interest and a detectable group or a precursor thereof. The probes and probe systems can detect spatiotemporal interactions of proteins or cells. In some embodiments, the interactions can be detected in live cells. Also described are methods of detecting the biological interactions.

POLYCYCLIC EPOXIDES AND COMPOSITIONS THEREOF WITH ANTI-CANCER ACTIVITIES

The present technology provides polycyclic epoxides of Formula I, compositions comprising such expoxides and methods of using such epoxides. In particular, these compounds are useful for inhibiting cancer cell proliferation and tumor angiogenesis or treating ovarian, breast, prostate, liver, pancreatic, and colon cancers, as well as leukemia.

Active/inactive dual-probe system for selective photoaffinity labeling of small molecule-binding proteins

Two are better than one: A new approach to selective photoaffinity labeling is described in which a bioactive probe is used in combination with its inactive analog as a scavenger of nonspecific proteins. Copyright

Synthesis and application of a photoaffinity analog of dehydroepiandrosterone (DHEA)

We have synthesized an analog of dehydroepiandrosterone (DHEA, 1) containing both a benzophenone (BP) and a biotin (Bt) group (DHEA-BP-Bt, 8). Compound 8 was prepared by functionalization on C-17 of 1. Biocytin was reacted with 4-benzoylbenzoic acid and t

New photoactivatable analogues of glutathione disulfide

New photoactivatable analogues of glutathione disulfide (GSSG) bearing new benzophenone-like photophores were synthesized by using an improved coupling reaction. Georg Thieme Verlag Stuttgart.