92021-33-5Relevant articles and documents
Consecutive three-component synthesis of 3-(hetero)aryl-1H-pyrazoles with propynal diethylacetal as a three-carbon building block
Levi, Lucilla,Boersch, Christina,Gers, Charlotte F.,Merkul, Eugen,Mueller, Thomas J. J.
, p. 9340 - 9356 (2011)
A novel consecutive three-component synthesis of 3-(hetero)aryl-1H- pyrazoles via room temperature Sonogashira arylation of propynal diethylacetal used as a propargyl aldehyde synthetic equivalent has been disclosed. The final acetal cleavage-cyclocondensation with hydrazine hydrochloride at 80 °C rapidly furnishes the title compounds in a one-pot fashion.