920299-33-8

Basic information

• Product Name: (R,S,S,S)-Nebivolol Hydrochloride
• Synonyms: (R,S,S,S)-Nebivolol Hydrochloride
• CAS NO: 920299-33-8
• Molecular Formula: C22H26ClF2NO4
• Molecular Weight: 441.8959464
• Mol File: 920299-33-8.mol
• Article Data: 29

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R,S,S,S)-Nebivolol Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R,S,S,S)-Nebivolol Hydrochloride(920299-33-8)
• EPA Substance Registry System: (R,S,S,S)-Nebivolol Hydrochloride(920299-33-8)

Safety Data

• Hazardous Substances Data: 920299-33-8(Hazardous Substances Data)

Usage

Uses

(R,S,S,S)-Nebivolol Hydrochloride is a β1-Adrenergic blocker. Used as an antihypertensive.

Upstream product

• 99199-60-7 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxylic acid 
• 99200-09-6 nebivolol 
• 99199-62-9 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol 
• 409346-73-2 6-fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde 
• 99199-90-3 6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran 
• 929706-85-4 α,α'-[[(phenylmethyl)imino]bismethylene]bis-[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol] 
• 1421916-53-1 C₂₉H₃₁F₂NO₄ 
• 1030385-16-0 (S)-2-benzylamino-1-((R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol 
• 303176-46-7 (R)-2-[(R)-6-fluoro-3,4-dihydro-2H-chromen-2-yl]-2-hydroxyethyl-4-methylbenzenesulfonate 
• 331729-56-7 2-benzyloxy-5-fluorobenzenemethanol 
• 129050-27-7 (R*,R*)-(±)-α-[(benzylamino)methyl](6-fluoro-2-chromanyl)methanol 

Relevant articles and documents

Synthesis of intermediate compound and [...] (by machine translation)

Synthesis of intermediate compounds [a] and [...]. [Solution] a [...], asymmetric epoxidation, sulfonyl halide in the presence of base catalyst by sulfonation, alkylation of amines, such as synthesized by a series of cross-coupling reaction. [Effect] [...] important from the viewpoint of pharmacological value, high efficiency, low cost, and which meets the requirements of industrial, optical isomers may be prepared [...] and develop a method, which is very economical in social benefit. [Drawing] no (by machine translation)

Nebivolol synthetic method and intermediate compounds of the

The present invention relates to a synthesis method and an intermediate compound of nebivolol. Specifically the invention relates to the method for synthesizing the nebivolol, the intermediate compound of the nebivolol, and a method for preparing the intermediate compound.

PROCESS FOR PREPARATION OF NEBIVOLOL AND IT'S SALTS

The present invention discloses a new process for preparation of Nebivolol or it's pharmaceutically acceptable salt. More particularly, the invention discloses an improved economical process for the preparation of intermediate, 6-fluoro-3,4- dihydro-2H-1-benzopyran-2-carboxaldehyde of Formula – II, converting the 6- fluoro-3,4-dihydro-2H-1-benzopyran-2-carboxaldehyde of Formula – II into mixture of [R*(S*)]-6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran and [R*(R*)]-6-fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran of Formula-V and separation of diastereomers of (R*)-6-Fluoro-3,4-dihydro-2-((S*)-oxiran-2-yl)- 2H-benzopran by forming azeotrope.