92037-01-9Relevant academic research and scientific papers
KINETICS OF THE REACTION OF PIPERAZINE WITH 1-METHOXY-2,3-EPOXYPROPANE
Mislyuk, O. A.,Shibaev, V. I.,V'yunov, K. A.,Ginak, A. I.
, p. 2000 - 2003 (2007/10/02)
The quantitative relationships governing the formation of N-alkyl and N,N'-dialkylpiperazines were studied.An increase in the yield of the N-alkylpiperazines can be achieved by increasing the temperature and reducing the concentration of the α-oxide in the reaction mass.Comparison of the two investigated reactions indicates that a push-pull mechanism involving two molecules of the reagents and a solvent molecule is realized.
SYNTHESIS OF MONO- AND BIS(HYDROXYALKYL)PIPERAZINES.
Mislyuk,Shibaev,Davidenkov,V'yunov,Ginak
, p. 1982 - 1983 (2007/10/02)
The known methods for production of mono- and bis(hydroxyalkyl)piperazines are based on the reaction of ethylene oxide with unsubstituted piperazine, but the connection between alkylation of piperazine and the side reaction of oligomerization of alpha -oxides under the influence of catalytic amounts of piperazine has still not been clarified. The interaction of piperazine with substituted alpha -oxides has not been studied at all. We showed with reference to the reactions of piperazine with substituted alpha -oxides that opening of the oxirane ring proceeds exclusively with formation of mono- (I-IV) and N,N prime -bis(hydroxyalkyl)piperazines (V-VIII) in yields of 85-95% calculated on the alpha -oxide. The authors show that the two molecules of the asymmetric alpha -oxide add on exclusively at the nitrogen atoms of the heterocycle, and that oligomerization of the alpha -oxide and addition of its second molecule at the hydroxyl groups of mono(hydroxyalkyl)piperazines (I-IV) make no appreciable contribution. The presence of free hydroxyl groups in compounds (I-VIII) offers possibilities of chemical bonding in epoxy compositions.
