92069-46-0Relevant academic research and scientific papers
Synthesis and photoinitiating properties of N-substituted 2,6-diisopropylanilines
Kolchina,Shekleina,Shelkovnikov
experimental part, p. 855 - 861 (2011/10/02)
Reactions of 2,6-diisopropylaniline and its 4-bromo and 4-thiocyanato derivatives with methyl iodide in dimethylformamide in the presence of potassium carbonate gave exclusively the corresponding N,N-dimethyl-substituted products. Heating of 2,6-diisopropylaniline and 2,6-diisopropyl-4-thiocyanatoaniline with methyl iodide without a solvent afforded only N-methyl derivatives. Pleiades Publishing, Ltd., 2011.
Diethylzinc/CuII-mediated alkylation of aromatic amines and related compounds
Brielles, Cédric,Harnett, Jerry J,Doris, Eric
, p. 8301 - 8302 (2007/10/03)
A mild and efficient method for the N-alkylation of aromatic amines and related compounds is described. The approach developed herein utilizes, as the key step, a transmetallation between a cupric salt and the dialkylzinc species.
ACAT inhibitors derived from hetero-Diels-Alder cycloadducts of thioaldehydes
Wilde, Richard G.,Billheimer, Jeffrey T.,Germain, Sandie J.,Hausner, Elizabeth A.,Meunier, Paul C.,Munzer, Deborah A.,Stoltenborg, Janet K.,Gillies, Peter J.,Burcham, Deborah L.,Huang, Shiew-Mai,Klaczkiewicz, John D.,Ko, Soo S.,Wexler, Ruth R.
, p. 1493 - 1513 (2007/10/03)
Acyl-CoA:cholesterol acyltransferase (ACAT) is the enzyme largely responsible for intracellular cholesteror esterification. A systemic inhibitor of ACAT is believed to be able to slow or even reverse the atherosclerotic process. Towards that goal, a series of cyclic sulfides, derived from the hetero-Diels-Alder reaction of thioaldehydes with 1,3-dienes, and bearing carboxamide substituents, were prepared and evaluated for in vitro (in several tissues and species) and ex vivo ACAT inhibition. Minor changes in subsequent structure were found to have a significant effect in optimization of the biological activity of this series of compounds.
