920744-20-3Relevant academic research and scientific papers
Formal synthesis of TMC-69-6H via a one-pot enantioselective domino proline-mediated aldol/olefin homologation procedure
Vuong, Sophie,Brondel, Nicolas,Len, Christophe,Papot, Sébastien,Renoux, Brigitte
experimental part, p. 433 - 439 (2012/01/14)
Enantioselective synthesis of TMC-69-6H was accomplished from readily accessible pyridone derivative via a domino proline-mediated aldol reaction/olefin homologation, followed by tandem ring-closing and cross metathesis.
New strategy for the synthesis of phosphatase inhibitors TMC-69-6H and analogs
Brondel, Nicolas,Renoux, Brigitte,Gesson, Jean-Pierre
, p. 9305 - 9308 (2007/10/03)
An efficient method for the synthesis of antitumor TMC-69-6H and related analogs which have been demonstrated to be phosphatase (PTP1B, VHR, and PP1) inhibitors, is reported. This strategy involves two key steps: a diastereoselective aldol reaction and a
