920757-34-2Relevant academic research and scientific papers
Azapeptide derivatives as HIV protease inhibitors
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Page/Page column 36, (2009/01/24)
This invention relates to novel compounds of the Formula Ib: that are azapeptides, and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel azapeptide compounds that are derivatives of the HIV protease inhibitor atazanavir sulfate. This invention also provides pyrogen-free compositions comprising one or more compounds of the invention and a carrier, and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are treated by administering HIV protease inhibitors. The invention also relates to the use of one or more of the disclosed compounds as reagents in analytical studies involving atazanavir.
A facile and efficient synthesis of d3-labelled Reyataz
Zhang, Huiping,Bonacorsi Jr., Samuel J.,Chen, Bang-Chi,Leith, Leslie W.,Rinehart, J. Kent,Balasubramanian, Balu,Barrish, Joel C.
, p. 1041 - 1047 (2007/10/03)
A facile and efficient synthesis of d3-labelled Reyataz is described. The key step of synthesis involved the coupling of N-(d 3-methoxycarbonyl)-L-tert-leucine 2b with an advanced chiral non-racemic building block 4. The latter was synthesized in 4 steps from the readily accessible hydrazine derivative 8. Copyright
