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tert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate
Cas No: 198904-85-7
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality Tert-Butyl 2-(4-(Pyridin-2-Yl)Benzyl)Hydrazinecarboxylate supplier in China
Cas No: 198904-85-7
No Data 1 Kilogram 30 Metric Ton/Month Simagchem Corporation Contact Supplier
tert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate
Cas No: 198904-85-7
USD $ 1.0-2.0 / Metric Ton 1 Metric Ton 100 Metric Ton/Week Hebei yanxi chemical co.,LTD. Contact Supplier
2-[[4-(2-Pyridinyl)phenyl]methyl]-hydrazinecarboxylic?acid
Cas No: 198904-85-7
No Data 1 Kilogram 20 Metric Ton/Month Henan Allgreen Chemical Co.,Ltd Contact Supplier
Hydrazinecarboxylicacid,2-[[4-(2-pyridinyl)phenyl]methyl]-,1,1-dimethylethylester
Cas No: 198904-85-7
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
2-{[4-(2-Pyridinyl)-phenyl]-methyl}-hydrazinecarboxylic acid 1,1 dimethylethyl ester
Cas No: 198904-85-7
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
tert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate CAS: 198904-85-7
Cas No: 198904-85-7
USD $ 1.0-2.0 / Metric Ton 5 Metric Ton 2500 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
tert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate
Cas No: 198904-85-7
USD $ 5.0-5.0 / Gram 1 Gram 100 Metric Ton/Year Jinan Finer Chemical Co., Ltd Contact Supplier
cheap Hydrazinecarboxylicacid,2-[[4-(2-pyridinyl)phenyl]methyl]-, 1,1-dimethylethyl ester bulk supply reliable quality 198904-85-7
Cas No: 198904-85-7
USD $ 1.0-1.0 / Kilogram 1 Kilogram 100 Kilogram/Month Shenzhen Tianyuan Pharmaceutical Technology Co., Ltd Contact Supplier
198904-85-7 tert-Butyl 2-(4-(pyridin-2-yl)benzyl)hydrazinecarboxylate
Cas No: 198904-85-7
No Data 1 Metric Ton 100 Metric Ton/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier

198904-85-7 Usage

Chemical Properties

White Solid

Uses

An intermediate for the preparation of antiviral protease inhibitors.
InChI:InChI=1/C17H21N3O2/c1-17(2,3)22-16(21)20-19-12-13-7-9-14(10-8-13)15-6-4-5-11-18-15/h4-11,19H,12H2,1-3H3,(H,20,21)

198904-85-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-Boc-2-[4-(2-pyridinyl)benzylidene]hydrazine

1.2 Other means of identification

Product number -
Other names tert-butyl N-[(4-pyridin-2-ylphenyl)methylamino]carbamate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:198904-85-7 SDS

198904-85-7Synthetic route

2-[4-(2-pyridinyl)phenyl]methylenehydrazinecarboxylic acid tert-butyl ester
198904-84-6

2-[4-(2-pyridinyl)phenyl]methylenehydrazinecarboxylic acid tert-butyl ester

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

Conditions
ConditionsYield
With hydrogen; sodium carbonate; triethylamine; 5%-palladium/activated carbon at 40℃; under 760.051 Torr; for 8h;99.76%
With hydrogen; 5%-palladium/activated carbon at 5 - 58℃; under 1520.1 Torr; for 5 - 8h; Nitrogen;99.14%
With hydrogen; palladium on carbon In methanol under 517.162 Torr; for 4h;96.5%
2-[4-(2-pyridinyl)phenyl]methylenehydrazinecarboxylic acid tert-butyl ester
198904-84-6

2-[4-(2-pyridinyl)phenyl]methylenehydrazinecarboxylic acid tert-butyl ester

A

2-(4-methylphenyl)pyridine
4467-06-5

2-(4-methylphenyl)pyridine

B

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

Conditions
ConditionsYield
With hydrogen; triethylamine; 5%-palladium/activated carbon at 40℃; under 760.051 Torr; for 5h;A 0.69%
B 99.17%
With hydrogen; sodium carbonate; 5%-palladium/activated carbon at 40℃; under 760.051 Torr; for 5h;A 0.25%
B 99.16%
With hydrogen; 5%-palladium/activated carbon In methanol at 50℃; under 760.051 Torr; for 5h;A 2.69%
B 97.11%
at 40 - 62℃; under 1520.1 Torr; for 5h; Hydrogen/nitrogen (1/2);A 0.1%
B 97.2%
With hydrogen; 5%-palladium/activated carbon at 5 - 58℃; under 1520.1 Torr; for 5 - 8h; Nitrogen gas;A 2.11%
B 94.41%
N-(tert-butoxycarbonyl)-N'-[4-(pyridin-2-yl)phenylmethylidene]hydrazine
857904-11-1

N-(tert-butoxycarbonyl)-N'-[4-(pyridin-2-yl)phenylmethylidene]hydrazine

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

Conditions
ConditionsYield
With hydrogen; palladium 10% on activated carbon In methanol for 4h;98%
With hydrogen; palladium 10% on activated carbon In methanol98%
With hydrogen; palladium on activated charcoal In methanol89%
2-[4-(2-pyridinyl)phenyl]methylenehydrazinecarboxylic acid tert-butyl ester
198904-84-6

2-[4-(2-pyridinyl)phenyl]methylenehydrazinecarboxylic acid tert-butyl ester

A

N-(tert-butoxycarbonyl)-N'-[4-5 (pyridin-2-yl)phenylmethylidene]hydrazine

N-(tert-butoxycarbonyl)-N'-[4-5 (pyridin-2-yl)phenylmethylidene]hydrazine

B

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

Conditions
ConditionsYield
palladium-carbon In n-heptane; hydrogenA n/a
B 84%
2-(4-formylphenyl)pyridine
127406-56-8

2-(4-formylphenyl)pyridine

t-butoxycarbonylhydrazine
870-46-2

t-butoxycarbonylhydrazine

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

Conditions
ConditionsYield
With borane pyridine; acetic acid In methanol at 0 - 20℃; for 2h;78%
2-bromo-pyridine
109-04-6

2-bromo-pyridine

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) Mg, I2, 2.) <1,3-bis(diphenylphosphino)propane>nickel(II) chloride, diisobutylaluminum hydride, 3.) aq. HCl
2: 93 percent / ethanol / 4 h / Heating
3: 89 percent / H2 / 10percent Pd/C / methanol
View Scheme
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol; water / 150 °C / 6750.68 Torr / Sealed tube; Microwave irradiation
2: trimethylsilyl trifluoromethanesulfonate / toluene; isopropyl alcohol / 22 - 50 °C / Microwave irradiation; Sealed tube
3: palladium 10% on activated carbon; sodium formate / ethanol; water / 1.5 h / 57 °C
View Scheme
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 20 h / 76 °C / Inert atmosphere
2: toluene; isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere; Large scale
3: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C
View Scheme
Multi-step reaction with 3 steps
1: palladium diacetate; triphenylphosphine; potassium hydroxide / methanol; tetrahydrofuran / 24 h / 60 °C / Inert atmosphere; Schlenk technique
2: toluene; isopropyl alcohol / 16 h / 20 - 85 °C / Inert atmosphere; Schlenk technique
3: palladium 10% on activated carbon; sodium formate / ethanol; water
View Scheme
2-(4-formylphenyl)pyridine
127406-56-8

2-(4-formylphenyl)pyridine

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 93 percent / ethanol / 4 h / Heating
2: 89 percent / H2 / 10percent Pd/C / methanol
View Scheme
Multi-step reaction with 2 steps
1: toluene; isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere; Large scale
2: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C
View Scheme
Multi-step reaction with 2 steps
1: toluene; isopropyl alcohol / 16 h / 20 - 85 °C / Inert atmosphere; Schlenk technique
2: palladium 10% on activated carbon; sodium formate / ethanol; water
View Scheme
1,1-dimethoxy-1-(4-bromophenyl)methane
24856-58-4

1,1-dimethoxy-1-(4-bromophenyl)methane

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 1.) Mg, I2, 2.) <1,3-bis(diphenylphosphino)propane>nickel(II) chloride, diisobutylaluminum hydride, 3.) aq. HCl
2: 93 percent / ethanol / 4 h / Heating
3: 89 percent / H2 / 10percent Pd/C / methanol
View Scheme
4-formylphenylboronic acid,
87199-17-5

4-formylphenylboronic acid,

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol; water / 150 °C / 6750.68 Torr / Sealed tube; Microwave irradiation
2: trimethylsilyl trifluoromethanesulfonate / toluene; isopropyl alcohol / 22 - 50 °C / Microwave irradiation; Sealed tube
3: palladium 10% on activated carbon; sodium formate / ethanol; water / 1.5 h / 57 °C
View Scheme
Multi-step reaction with 3 steps
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 20 h / 76 °C / Inert atmosphere
2: toluene; isopropyl alcohol / 2 h / 80 - 85 °C / Inert atmosphere; Large scale
3: palladium 10% on activated carbon; sodium formate / water; ethanol / 1.5 h / 57 °C
View Scheme
Multi-step reaction with 3 steps
1: palladium diacetate; triphenylphosphine; potassium hydroxide / methanol; tetrahydrofuran / 24 h / 60 °C / Inert atmosphere; Schlenk technique
2: toluene; isopropyl alcohol / 16 h / 20 - 85 °C / Inert atmosphere; Schlenk technique
3: palladium 10% on activated carbon; sodium formate / ethanol; water
View Scheme
(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane
98760-08-8

(2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
In isopropyl alcohol for 24h; Inert atmosphere; Reflux; Large scale;85.4%
In isopropyl alcohol Heating / reflux;75%
In isopropyl alcohol for 16h; Heating;69%
C20H32NO7P
1003888-91-2

C20H32NO7P

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

C37H53N4O9P
1003888-92-3

C37H53N4O9P

Conditions
ConditionsYield
In isopropyl alcohol at 80℃; for 15h;78%
(2S)-3-methyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanoic Acid
853893-93-3

(2S)-3-methyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanoic Acid

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

tert-butyl 2-{(2S,3S)-2-hydroxy-3-[((2S)-3-methyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-4-phenylbutyl}-2-[4-(2-pyridinyl)benzyl]hydrazinecarboxylate

tert-butyl 2-{(2S,3S)-2-hydroxy-3-[((2S)-3-methyl-2-{3-[(2-methyl-1,3-thiazol-4-yl)methyl]-2-oxo-1-imidazolidinyl}butanoyl)amino]-4-phenylbutyl}-2-[4-(2-pyridinyl)benzyl]hydrazinecarboxylate

Conditions
ConditionsYield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine In tetrahydrofuran; DMF (N,N-dimethyl-formamide) at 25℃; for 16h;75%
2,2,2-Trifluoro-N-((S)-1-oxiranyl-2-phenyl-ethyl)-acetamide

2,2,2-Trifluoro-N-((S)-1-oxiranyl-2-phenyl-ethyl)-acetamide

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

1-[4-(Pyridin-2-yl)-phenyl]-4(S)-hydroxy-2-(N-Boc-amino)-5(S)-trifluoroacetyl-amino-6-phenyl-2-azahexane
198905-11-2

1-[4-(Pyridin-2-yl)-phenyl]-4(S)-hydroxy-2-(N-Boc-amino)-5(S)-trifluoroacetyl-amino-6-phenyl-2-azahexane

Conditions
ConditionsYield
In isopropyl alcohol at 80℃; for 16h;60%
(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester
98760-08-8, 98818-34-9, 98818-35-0, 103127-56-6, 98737-29-2

(1-oxiranyl-2-phenylethyl)carbamic acid tert-butyl ester

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane
198904-86-8

1-[4-(pyridine-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxycarbonyl)amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
In isopropyl alcohol at 65℃; for 16h;57%
In isopropyl alcohol at 65 - 85℃; for 16h; Product distribution / selectivity;35%
In isopropyl alcohol at 85℃; for 16h;35%
N-methoxycarbonyl-L-valine
111398-44-8, 74761-42-5

N-methoxycarbonyl-L-valine

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

Methyl (1S)-2-methyl-1-({2-[4-(2-pyridinyl)benzyl]hydrazino}carbonyl)propylcarbamate
857904-23-5

Methyl (1S)-2-methyl-1-({2-[4-(2-pyridinyl)benzyl]hydrazino}carbonyl)propylcarbamate

Conditions
ConditionsYield
Stage #1: N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine With trifluoroacetic acid In dichloromethane at 25℃; for 1h;
Stage #2: N-methoxycarbonyl-L-valine With N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one In tetrahydrofuran at 25℃; for 3h;
47%
Stage #1: N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine With trifluoroacetic acid In dichloromethane at 25℃; for 1h;
Stage #2: N-methoxycarbonyl-L-valine With N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one In tetrahydrofuran at 25℃; for 3h;
47%
(1S)-1-(2-oxiranyl)-2-phenyl-N-(trifluoromethyl)ethanamine
857904-14-4

(1S)-1-(2-oxiranyl)-2-phenyl-N-(trifluoromethyl)ethanamine

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

Tert-butyl 2-{(2S,3S)-2-hydroxy-4-phenyl-3-[(trifluoromethyl)amino]butyl}-2-[4-(2-pyridinyl)benzyl]hydrazinecarboxylate
857904-15-5

Tert-butyl 2-{(2S,3S)-2-hydroxy-4-phenyl-3-[(trifluoromethyl)amino]butyl}-2-[4-(2-pyridinyl)benzyl]hydrazinecarboxylate

Conditions
ConditionsYield
In isopropyl alcohol at 65℃; for 16h;28%
In isopropyl alcohol at 65℃; for 16h;28%
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

2(R)-3(S)-1,2-epoxy-3-phenylmethoxycarbonylamino-4-phenylbutane
137515-66-3

2(R)-3(S)-1,2-epoxy-3-phenylmethoxycarbonylamino-4-phenylbutane

tert-butyl 2-((2S,3S)-2-hydroxy-4-phenyl-3-{[(benzyloxy)carbonyl]amino}butyl)-2-(4-pyridin-2-ylbenzyl)hydrazinecarboxylate
1346891-05-1

tert-butyl 2-((2S,3S)-2-hydroxy-4-phenyl-3-{[(benzyloxy)carbonyl]amino}butyl)-2-(4-pyridin-2-ylbenzyl)hydrazinecarboxylate

Conditions
ConditionsYield
In isopropyl alcohol for 18h; Heating / reflux;7%
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

[ring-13C6]-N-(tert-butoxycarbonyl)-2(S)-amino-1-phenyl-3(R)-3,4-epoxy-bytane
1026616-57-8

[ring-13C6]-N-(tert-butoxycarbonyl)-2(S)-amino-1-phenyl-3(R)-3,4-epoxy-bytane

[ring-13C6]-1-[4-(pyridin-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxy-carbonyl)-amino]-4(S)-hydroxy-6-phenyl-2-azahexane
866017-17-6

[ring-13C6]-1-[4-(pyridin-2-yl)phenyl]-5(S)-2,5-bis[(tert-butyloxy-carbonyl)-amino]-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
In isopropyl alcohol at 75℃; for 12h;
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

1-(4-(pyridin-2-yl)benzyl)hydrazine
920757-34-2

1-(4-(pyridin-2-yl)benzyl)hydrazine

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran; water at 50℃; for 3h;
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

C42H40N6O7

C42H40N6O7

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: propan-2-ol / 24 h / 80 °C
2: HCl / dioxane / 4 h / 50 °C
3: Et3N / tetrahydrofuran / 8 h / 0 - 20 °C
View Scheme
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

C46H44N6O9

C46H44N6O9

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: propan-2-ol / 24 h / 80 °C
2: HCl / dioxane / 4 h / 50 °C
3: Et3N / tetrahydrofuran / 8 h / 0 - 20 °C
View Scheme
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

1-[4-(pyridin-2-yl)-phenyl]-4(S)-hydroxy-5(S)-2,5-diamino-6-phenyl-2-azahexane
437713-06-9

1-[4-(pyridin-2-yl)-phenyl]-4(S)-hydroxy-5(S)-2,5-diamino-6-phenyl-2-azahexane

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: propan-2-ol / 24 h / 80 °C
2: HCl / dioxane / 4 h / 50 °C
View Scheme
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

{2,2-dimethyl-1-[N-(4-pyridin-2-yl-benzyl)-hydrazinocarbonyl]-propyl}-carbamic acid methyl ester

{2,2-dimethyl-1-[N-(4-pyridin-2-yl-benzyl)-hydrazinocarbonyl]-propyl}-carbamic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HCl / tetrahydrofuran; H2O / 3 h / 50 °C
2: 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 / 1.5 h / 20 °C
View Scheme
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

(S)-{2,2-dimethyl-1-[N'-(4-pyridin-2-yl-benzyl)-hydrazinocarbonyl]-propyl}-carbamic acid methyl ester
857904-02-0

(S)-{2,2-dimethyl-1-[N'-(4-pyridin-2-yl-benzyl)-hydrazinocarbonyl]-propyl}-carbamic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: HCl / tetrahydrofuran; H2O / 3 h / 50 °C
2: 14.43 g / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 / 1.5 h / 20 °C
View Scheme
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

{(S)-1-[N'-((2S,3S)-3-amino-2-hydroxy-4-phenyl-butyl)-N'-(4-pyridin-2-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester
857900-54-0

{(S)-1-[N'-((2S,3S)-3-amino-2-hydroxy-4-phenyl-butyl)-N'-(4-pyridin-2-yl-benzyl)-hydrazinocarbonyl]-2,2-dimethyl-propyl}-carbamic acid methyl ester

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: HCl / tetrahydrofuran; H2O / 3 h / 50 °C
2: 14.43 g / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 / 1.5 h / 20 °C
3: 25 percent / propan-2-ol / 24 h / Heating
4: HCl / tetrahydrofuran; H2O / 5 h / 50 °C
View Scheme
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

{(1S,2S)-1-benzyl-2-hydroxy-3-[N'-((S)-2-methoxycarbonylamino-3,3-dimethyl-butyryl)-N-(4-pyridin-2-yl-benzyl)-hydrazino]-propyl}-carbamic acid tert-butyl ester
857904-03-1

{(1S,2S)-1-benzyl-2-hydroxy-3-[N'-((S)-2-methoxycarbonylamino-3,3-dimethyl-butyryl)-N-(4-pyridin-2-yl-benzyl)-hydrazino]-propyl}-carbamic acid tert-butyl ester

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: HCl / tetrahydrofuran; H2O / 3 h / 50 °C
2: 14.43 g / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 / 1.5 h / 20 °C
3: 25 percent / propan-2-ol / 24 h / Heating
View Scheme
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

C38H49(2)H3N6O7

C38H49(2)H3N6O7

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: HCl / tetrahydrofuran; H2O / 3 h / 50 °C
2: 14.43 g / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 / 1.5 h / 20 °C
3: 25 percent / propan-2-ol / 24 h / Heating
4: HCl / tetrahydrofuran; H2O / 5 h / 50 °C
5: 78 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / K2HPO4 / CH2Cl2; H2O / 12 h / 20 °C
View Scheme
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

atazanavir
198904-31-3

atazanavir

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: HCl / tetrahydrofuran; H2O / 3 h / 50 °C
2: 14.43 g / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2 / 1.5 h / 20 °C
3: 25 percent / propan-2-ol / 24 h / Heating
4: HCl / tetrahydrofuran; H2O / 5 h / 50 °C
5: 95 percent / 1-hydroxybenzotriazole; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; ethyldiisopropylamine / CH2Cl2
View Scheme
Multi-step reaction with 3 steps
1: 69 percent / propan-2-ol / 16 h / Heating
2: 100 percent / aq. HCl / tetrahydrofuran / 4 h / 50 °C
3: 1.) O-(1,2-dihydro-2-oxo-1-pyridyl)-N,N,N',N'-tetramethyluronium tetrafluoroborate, N-ethyldiisopropylamine / 1.) CH2Cl2, 0 deg C, 20 min, 2.) CH2Cl2, overnight
View Scheme
Multi-step reaction with 3 steps
1: isopropyl alcohol / 24 h / Inert atmosphere; Reflux; Large scale
2: hydrogenchloride / tetrahydrofuran / 3 h / 22 - 55 °C / Large scale
3: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 22 - 25 °C / Large scale
View Scheme
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

C16(13)C6H26N4O*3ClH

C16(13)C6H26N4O*3ClH

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: propan-2-ol / 12 h / 75 °C
2: HCl / tetrahydrofuran; H2O / 30 h / 60 °C
View Scheme
N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine
198904-85-7

N-1-(tert-butoxycarbonyl)-N-2-[4-(pyridine-2-yl)benzyl]hydrazine

[ring-13C6]-1-[4-(pyridin-2-yl)phenyl]-5(S)-2,5-bis{[N-(methoxy-carbonyl)-L-tert-leycinyl]amino}-4(S)-hydroxy-6-phenyl-2-azahexane

[ring-13C6]-1-[4-(pyridin-2-yl)phenyl]-5(S)-2,5-bis{[N-(methoxy-carbonyl)-L-tert-leycinyl]amino}-4(S)-hydroxy-6-phenyl-2-azahexane

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: propan-2-ol / 12 h / 75 °C
2: HCl / tetrahydrofuran; H2O / 30 h / 60 °C
3: 0.899 g / 1-hydroxybenzotriazole hydrate; 1-[3-(dimethylamino)-propyl]-3-ethyl-carbodiimide*HCl; diisopropylethylamine / CH2Cl2 / 17 h / 20 °C
View Scheme

198904-85-7Upstream product

198904-85-7Downstream Products

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