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Synthesis of 5-(1H-benzimidazol-2-yl)-1H-pyrazolo-[3,4-b]pyridines by the p-(dimethylamino)benzaldehyde modification of Hantzsch reaction
Dzvinchuk
, p. 474 - 479 (2008/12/21)
The reactions of p-(dimethylamino)benzaldehyde with 5-amino-3-methyl-1- phenylpyrazole and 2-RCOCH2-1H-benzimidazoles have produced 5-(1H-benzimidazol-2-yl)-1H-pyrazolo[3,4-b]pyridines. The transformation includes the formation of compounds in accordance with a Hantzsch reaction containing a 1,4-dihydropyridine ring, and is completed by the aromatization either by the splitting off of N,N-dimethylanyline or oxidation. The splitting is produced by acetic acid and the oxidation by a nitrocompound.
