92087-19-9

Upstream product

• 25802-67-9 4-nitro-2-thiocyanato-benzoic acid 
• 619-17-0 4-Nitroanthranilic acid 
• 7440-44-0 pyrographite 
• 140-89-6 potassium ethyl xanthogenate 

Downstream Products

• 2597-58-2 2-ethylsulfanyl-4-nitro-benzoic acid 
• 2486-76-2 2-ethylsulfanyl-4-amino-benzoic acid 
• 345910-57-8 4-amino-2-mercapto-benzoic acid ethyl ester 
• 409112-34-1 C₇H₃Cl₂NO₃S 
• 78334-06-2 4-amino-2-mercapto-benzoic acid 
• 150443-58-6 2-mercapto-4-nitrobenzoic acid 

Relevant academic research and scientific papers

Pharmaceutically active benzoquinazoline compounds

Compounds of formula (I) or salts thereof, wherein the dotted line represents a single or double bond, R1is alkyl or amino optionally substituted by alkyl, alkanoyl or benzyl group; R2, R3, R4and R5are the same or different and each is selected from hydrogen, phenyl, halo, nitro, a group S(O)nR8wherein n is the integer 0, 1 or 2 and R8is halo or alkyl or a group NR9R10wherein R9and R10are both hydrogen, a group NR11R12wherein R11and R12are the same or different and each is hydrogen or alkyl, a group OR13wherein R13is hydrogen or C1-4alkyl optionally substituted by halo; a C1-4aliphatic group optionally substituted by a group OR14or NR14R15wherein R14and R15are the same or different and each is hydrogen or alkyl; or two of R2to R5are linked together to form a benzo group, or one of R2to R5is a group -X-Y-R16wherein X is CH2, NR17, CO or S(O)m, and Y is CH2, NR17, O, or S(O)m, or -X-Y- is a group -O-, -NR17-, -CH=CH- or -N=N-, are disclosed as pharmacological agents useful in the treatment of tumours. Pharmaceutical compositions and methods for the preparation of compounds of formula (I) are also described.

PHARMACEUTICAL COMPOUNDS

The present invention relates to novel benzoquinazoline thymidylate synthase inhibitors, to pharmaceutical formulations containing them and to their use in medicine

Benzoquinazoline Inhibitors of Thymidylate Synthase: Methylenediamino-Linked Aroylglutamate Derivatives

Syntheses of several new inhibitors of thymidylate synthase (TS) structurally related to folic acid are described in which the pterin portion of the folate molecule is replaced by a benzoquinazoline moiety, but which retain the natural methyleneamino l

Anti-asthmatic tetrazolyl 6H-dibenz-[B,E]-[1,4]-oxathiepin derivatives, compositions, and method of use therefor

Novel 6H-dibenz[b,e][1,4]oxathiepin derivatives of the formulae I and Ia are employed in the treatment and control of allergic conditions such as allergic asthma. STR1

Anti-asthmatic 6H-dibenz-[b,e] [1,4]oxathiepin derivatives, compositions, and method of use therefor

Novel 6H-dibenz[b,e] [1,4]oxathiepin derivatives of the formula I and Ia are employed in the treatment and control of allergic conditions such as allergic asthma. STR1

6H-Dibenz[b,e][1,4]oxathiepin derivatives

Novel 6H-dibenz[b,e][1,4]oxathiepin derivatives of the formulae I and IA are employed in the treatment and control of allergic conditions such as allergic asthma. STR1