920965-87-3

Usage

Uses

Used in Pharmaceutical Industry:
4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile is used as a building block in organic synthesis for the development of pharmaceutical substances. Its chemical properties contribute to the creation of biologically active compounds, which are essential in the formulation of various medications.
Used in Agrochemical Industry:
In the agrochemical sector, 4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile serves as a key intermediate in the synthesis of agrochemicals. Its role in this industry is pivotal for the production of compounds that are used to protect crops and enhance agricultural productivity.
Used in Organic Synthesis:
4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile is utilized as a valuable intermediate in organic synthesis processes. Its unique structure and reactivity allow for the development of a wide range of chemical products, making it an indispensable component in various chemical manufacturing endeavors.

InChI:InChI=1/C8H4ClN3/c9-6-1-2-11-8-7(6)5(3-10)4-12-8/h1-2,4H,(H,11,12)

Upstream product

• 918515-16-9 4-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde 
• 55052-28-3 4-chloro-7-azaindole 
• 920965-86-2 1-(benzenesulfonyl)-4-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 
• 1004991-98-3 (E)-4-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde oxime 

Downstream Products

• 869335-73-9 4-chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine 
• 869335-20-6 4-chloro-3-iodo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine 

Relevant academic research and scientific papers

PYRROLO[2,3-B]PYRIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER

The present application relates to a compound of Formula I, or a salt, hydrate or solvate thereof, as defined herein. The present compounds are found to have pharmacological effects, particularly at MRCK. Further provided are pharmaceutical compositions comprising said compounds. The present invention also relates to the use of these compounds as therapeutic agents, in particular, for the treatment and/or prevention of proliferative diseases, such as cancer.

1H-PYRROLO[2,3-B]PYRIDINE DERIVATIVES USEFUL AS HSP90 INHIBITORS

Compounds of formula (I) have HSP90 inhibitory activity: ring A is an aryl or heteroaryl ring or ring system; R1 is hydrogen, fluoro, chloro, bromo, or a radical of formula (1A): -X-Alk1-(Z)m-(Alk2)n-Q (IA) wherein X is a bond, -O-, -S-, -S(O)-, -SO2-, or -NH-, Z is -O-, -S-, -(C=O)-, -(C=S)-, -S(O)-, -SO2-, -NRA-, or, in either orientation -C(=O)O-, -C(=O)NRA-, -C(=S)NRA-, -SO2NRA-, -NRAC(=O)-, or -NRASO2- wherein RA is hydrogen or C1-C6 alkyl in which one or more hydrogens is optionally substituted by fluorine;Alk1 and AIk2 are optionally substituted divalent C1-C3 alkylene:or C2-C3 alkenylene radicals, m and n are independently 0 or 1, and Q is hydrogen or an optionally substituted carbocyclic or heterocyclic radical; R2 is cyano (-CN), fluoro, chloro, bromo, methyl, ethyl, -OH, -CH2OH, -C(=O)NH2,-C(=O)H, -C(=O)CH3, or -NH2; R3 and R4 are independently selected from hydrogen, fluoro, chloro, bromo, cyano (-CN), C1-C3alkyl optionally substituted with one or more fluorine substituents, C1-C3alkoxy optionally substituted with one or more fluorine substituents, -CH=CH2, -C≡CH, cyclopropyl and -NH2, or R3 and R4 together represent methylenedioxy (-OCH2O-) or ethylenedioxy (-OCH2CH2O-) in either of which one or more hydrogens are optionally replaced by fluorine; S1 is as defined in the description.

AMINE DERIVATIVES USEFUL AS ANTICANCER AGENTS

The invention relates to compounds of formula (I), or a pharmaceutically acceptable salt thereof, wherein: A is a moiety of formula (Il) and to pharmaceutically acceptable salts and solvates thereof, wherein X, Z, D, E, V, W, Y, R1, R2, R5, R6, L, and u are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of formula I to a patient in need thereof, and to compositions for treating such disorders which contain the compounds of formula (I). The invention also relates to methods of making the compounds of formula (I).

NOVEL COMPOUNDS

The invention relates to compound of the formula (I) or its salt, wherein -R1, -R2, -R3, -R4, -R5, -M-, -X- and -Y= are as defined in the description, their use of as, medicament, the process for their preparation and use for the treatment of JAK3 mediated diseases.