918515-16-9

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 4-chloro-
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 4-chloro-;4-Chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde;4-Chloro-3-formyl-7-azaindole;4-Chloro-7-azaindole-3-carbaldehyde
• CAS NO: 918515-16-9
• Molecular Formula: C₈H₅ClN₂O
• Molecular Weight: 180.59
• Product Categories: Heterocycle-Pyridine series
• Mol File: 918515-16-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 372.6 °C at 760 mmHg
• Flash Point: 179.1 °C
• Appearance: /
• Density: 1.521 g/cm³
• Vapor Pressure: 9.53E-06mmHg at 25°C
• Refractive Index: 1.748
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• PKA: 11.48±0.40(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 4-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 4-chloro-(918515-16-9)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 4-chloro-(918515-16-9)

Safety Data

• Hazardous Substances Data: 918515-16-9(Hazardous Substances Data)

Usage

General Description

4-chloro-1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde is a chemical compound with the molecular formula C9H6ClNO. It is a yellow solid that is commonly used in the synthesis of pharmaceuticals and agrochemicals. 1H-Pyrrolo[2,3-b]pyridine-3-carboxaldehyde, 4-chloro- is known for its versatile reactivity and is often used as a building block in organic synthesis. It is commonly utilized in the production of various heterocyclic compounds and plays a crucial role in the development of new drugs and advanced materials. Its unique structure and reactivity make it an important intermediate in organic chemistry and drug discovery.

InChI:InChI=1/C8H5ClN2O/c9-6-1-2-10-8-7(6)5(4-12)3-11-8/h1-4H,(H,10,11)

Upstream product

• 55052-28-3 4-chloro-7-azaindole 
• 100-97-0 hexamethylenetetramine 

Downstream Products

• 869335-20-6 4-chloro-3-iodo-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine 
• 869335-73-9 4-chloro-3-iodo-1H-pyrrolo[2,3-b]pyridine 
• 920965-87-3 4-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonitrile 
• 1119282-72-2 4-chloro-N-[(1-pyridin-3-ylcyclohexyl)methyl]-1-pyrimidin-2-yl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide 

Relevant articles and documents

PYRROLO[2,3-B]PYRIDINE COMPOUNDS AND THEIR USE IN THE TREATMENT OF CANCER

The present application relates to a compound of Formula I, or a salt, hydrate or solvate thereof, as defined herein. The present compounds are found to have pharmacological effects, particularly at MRCK. Further provided are pharmaceutical compositions comprising said compounds. The present invention also relates to the use of these compounds as therapeutic agents, in particular, for the treatment and/or prevention of proliferative diseases, such as cancer.

HETEROARYL AMIDE ANALOGUES

Compounds, pharmaceutical compositions, and methods of use are disclosed for heteroaryl amide analogues of formula Ia and/or Ib: . In certain embodiments, the heteroaryl amide analogues are agonists and/or ligands of dopamine receptors and may be useful, inter alia, for the treatment of a condition responsive to P2X7 receptor modulation, for example, pain, inflammation, a neurological or neurodegenerative disorder, a cardiovascular disorder, an ocular disorder or an immune system disorder.

HETEROARYL AMIDE ANALOGUES

Compounds, pharmaceutical compositions, and methods of use are disclosed for heteroaryl amide analogues of formula Ia and/or Ib. In certain embodiments, the heteroaryl amide analogues are agonists and/or ligands of dopamine receptors and may be useful, inter alia, for the treatment of a condition responsive to P2X7 receptor modulation, for example, pain, inflammation, a neurological or neurodegenerative disorder, a cardiovascular disorder, an ocular disorder or an immune system disorder.