92097-99-9

Upstream product

• 106-57-0 Glycine anhydride 
• 2746-25-0 p-Methoxybenzyl bromide 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 117471-52-0 1,4-bis(p-methoxybenzyl)-3-methoxy-2,5-piperazinedione 
• 130806-27-8 3,6-dimethoxy-1,4-di(p-methoxybenzyl)piperazine-2,5-dione 
• 1024013-27-1 (3R,6S)-3,6-dibenzyl-1,4-bis(4-methoxybenzyl)piperazine-2,5-dione 
• 1024013-29-3 (3R,6S)-3,6-diethyl-1,4-bis(4-methoxybenzyl)piperazine-2,5-dione 
• 1024013-02-2 3-allyl-1,4-bis(4-methoxybenzyl)piperazine-2,5-dione 
• 1024013-03-3 (3R,6S)-3,6-diallyl-1,4-bis(4-methoxybenzyl)piperazine-2,5-dione 
• 95676-25-8 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-2,5-piperazinedione 
• 92098-10-7 3,6-dibromo-1,4-bis(4-methoxybenzyl)piperazine-2,5-dione 
• 95676-09-8 1,4-bis(p-methoxybenzyl)-3-bromo-2,5-piperazinedione 
• 95676-21-4 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (anti) 
• 95676-22-5 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (syn) 
• 95723-23-2 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(2-valerolactonyl)-2,5-piperazinedione (anti, major diastereomer) 
• 95723-22-1 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(2-δ-valerolactonyl)-2,5-piperazinedione (syn, major diastereomer) 
• 95676-23-6 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(2-valerolactonyl)-2,5-piperazinedione (syn, minor diastereomer) 

Relevant academic research and scientific papers

EPIDITHIODIOXOPIPERAZINE COMPOUND OR ITS DERIVATIVES, AND THE USE THEREOF

The present invention relates to an epidithiodioxopiperazine derivative represented by the Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mim

Studies towards complex bridged alkaloids: regio- and stereocontrolled enolate chemistry of 2,5-diketopiperazines

The substitution of symmetrical N-protected diketopiperazines (DKPs) via enolate intermediates has been studied. The enolate reactions were highly diastereocontrolled, leading to enantiopure DKP products if chiral amino acid precursors were employed, and

Divergent, Generalized Synthesis of Unsymmetrically Substituted 2,5-Piperasinediones

N,N'-Disubstituted 2,5-piperazinediones (12) can be 3,6-dibrominated followed by displacement with sodium 2-mercaptopyridine to furnish syn-1,4-disubstituted 3,6-bis(2'-thiopyridyl)-2,5-piperazinediones (8) in high yield.Precomplexation of these sulfides with silver(I) triflate followed by addition of trimethylsilyl enol ethers leads to chemoselective C-C bond formation, furnishing the homologated piperazinediones 10.The remaining sulfide functionality of 10 is relatively inert to a second substitution.These electrophylic 2,5-piperazinediones provide access to relatively inaccessible, unsymmetrical 2,5-piperazinediones and provide advantages over the corresponding well-known enolate anion approach.Substrates that contain N-p-methoxybenzyl residues can be deprotected to the lipophobic N,N'-unsubstituted 2,5-piperazinediones with aqueous ceric ammonium nitrate.The diastereoselectivity observed in the coupling reactions is discussed in the context of a single crystal X-ray structure determination of 20.