92097-99-9

Basic information

• Product Name: 2,5-Piperazinedione, 1,4-bis[(4-methoxyphenyl)methyl]-
• CAS NO: 92097-99-9
• Molecular Formula: C20H22N2O4
• Molecular Weight: 354.406
• Mol File: 92097-99-9.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,5-Piperazinedione, 1,4-bis[(4-methoxyphenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Piperazinedione, 1,4-bis[(4-methoxyphenyl)methyl]-(92097-99-9)
• EPA Substance Registry System: 2,5-Piperazinedione, 1,4-bis[(4-methoxyphenyl)methyl]-(92097-99-9)

Safety Data

• Hazardous Substances Data: 92097-99-9(Hazardous Substances Data)

Upstream product

• 106-57-0 Glycine anhydride 
• 2746-25-0 p-Methoxybenzyl bromide 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 1024013-27-1 (3R,6S)-3,6-dibenzyl-1,4-bis(4-methoxybenzyl)piperazine-2,5-dione 
• 1024013-29-3 (3R,6S)-3,6-diethyl-1,4-bis(4-methoxybenzyl)piperazine-2,5-dione 
• 1024013-02-2 3-allyl-1,4-bis(4-methoxybenzyl)piperazine-2,5-dione 
• 1024013-03-3 (3R,6S)-3,6-diallyl-1,4-bis(4-methoxybenzyl)piperazine-2,5-dione 
• 130806-27-8 3,6-dimethoxy-1,4-di(p-methoxybenzyl)piperazine-2,5-dione 
• 117471-52-0 1,4-bis(p-methoxybenzyl)-3-methoxy-2,5-piperazinedione 
• 95676-21-4 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (anti) 
• 95676-22-5 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (syn) 
• 95723-23-2 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(2-valerolactonyl)-2,5-piperazinedione (anti, major diastereomer) 
• 95723-22-1 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(2-δ-valerolactonyl)-2,5-piperazinedione (syn, major diastereomer) 
• 95676-23-6 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(2-valerolactonyl)-2,5-piperazinedione (syn, minor diastereomer) 
• 95676-12-3 1,4-bis(p-methoxybenzyl)-3,6-bis(2'-thiopyridyl)-2,5-piperazinedione 
• 92216-27-8 1,4-dimethyl-3-(2'-thiopyridyl)-6-(2-γ-butyrolactonyl)-2,5-piperazinedione (anti, major diastereomer) 

Relevant articles and documents

EPIDITHIODIOXOPIPERAZINE COMPOUND OR ITS DERIVATIVES, AND THE USE THEREOF

The present invention relates to an epidithiodioxopiperazine derivative represented by the Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mim

Divergent, Generalized Synthesis of Unsymmetrically Substituted 2,5-Piperasinediones

N,N'-Disubstituted 2,5-piperazinediones (12) can be 3,6-dibrominated followed by displacement with sodium 2-mercaptopyridine to furnish syn-1,4-disubstituted 3,6-bis(2'-thiopyridyl)-2,5-piperazinediones (8) in high yield.Precomplexation of these sulfides with silver(I) triflate followed by addition of trimethylsilyl enol ethers leads to chemoselective C-C bond formation, furnishing the homologated piperazinediones 10.The remaining sulfide functionality of 10 is relatively inert to a second substitution.These electrophylic 2,5-piperazinediones provide access to relatively inaccessible, unsymmetrical 2,5-piperazinediones and provide advantages over the corresponding well-known enolate anion approach.Substrates that contain N-p-methoxybenzyl residues can be deprotected to the lipophobic N,N'-unsubstituted 2,5-piperazinediones with aqueous ceric ammonium nitrate.The diastereoselectivity observed in the coupling reactions is discussed in the context of a single crystal X-ray structure determination of 20.