920974-75-0Relevant academic research and scientific papers
CuI controlled C-C and C-N bond formation of heteroaromatics through C(sp3)-H activation
Xia, Ran,Niu, Hong-Ying,Qu, Gui-Rong,Guo, Hai-Ming
supporting information, p. 5546 - 5549 (2013/01/15)
A new method for C-C and C-N bond formation of heteroaromatics and C(sp3)-H alkanes was developed with high regioselectivity. The reaction occurred on C8 to give 8-cylcoakylpurines by C-C bond formation only promoted by tBuOOtBu, while it occurred on the amino group to give N6-alkylated purines by C-N bond formation when 2 equiv of CuI were added. A reaction mechanism was also proposed based on our preliminary experimental data.
N6-Cycloalkyl-2-substituted adenosine derivatives as selective, high affinity adenosine A1 receptor agonists
Elzein, Elfatih,Kalla, Rao,Li, Xiaofen,Perry, Thao,Marquart, Tim,Micklatcher, Mark,Li, Yuan,Wu, Yuzhi,Zeng, Dewan,Zablocki, Jeff
, p. 161 - 166 (2007/10/03)
A series of new selective, high affinity A1-AdoR agonists is reported. Compound 23 that incorporated a carboxylic acid functionality in the 4-position of the pyrazole ring displayed KiL value of 1 nM for the A1-AdoR and >5
