92098-10-7

Upstream product

• 92097-99-9 1,4-bis(4-methoxybenzyl)piperazine-2,5-dione 
• 824-94-2 p-methoxybenzyl chloride 
• 2746-25-0 p-Methoxybenzyl bromide 

Downstream Products

• 95676-12-3 1,4-bis(p-methoxybenzyl)-3,6-bis(2'-thiopyridyl)-2,5-piperazinedione 
• 130806-27-8 3,6-dimethoxy-1,4-di(p-methoxybenzyl)piperazine-2,5-dione 
• 95676-26-9 1,4-bis(p-methoxybenzyl)-3-(2'-γ-butyrolactonyl)-2,5-piperazinedione (major diastereomer) 
• 92216-26-7 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(2-γ-butyrolactonyl)-2,5-piperazinedione (syn, minor diastereomer) 
• 92216-28-9 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(2-γ-butyrolactonyl)-2,5-piperazinedione (anti, minor diastereomer) 
• 92098-11-8 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(2-γ-butyrolactonyl)-2,5-piperazinedione (syn, major diastereomer) 
• 92216-27-8 1,4-dimethyl-3-(2'-thiopyridyl)-6-(2-γ-butyrolactonyl)-2,5-piperazinedione (anti, major diastereomer) 
• 95676-23-6 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(2-valerolactonyl)-2,5-piperazinedione (syn, minor diastereomer) 
• 95723-22-1 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(2-δ-valerolactonyl)-2,5-piperazinedione (syn, major diastereomer) 
• 95723-23-2 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(2-valerolactonyl)-2,5-piperazinedione (anti, major diastereomer) 
• 95676-22-5 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (syn) 
• 95676-21-4 1,4-bis(p-methoxybenzyl)-3-(2'-thiopyridyl)-6-(dimethylmalonyl)-2,5-piperazinedione (anti) 

Relevant academic research and scientific papers

EPIDITHIODIOXOPIPERAZINE COMPOUND OR ITS DERIVATIVES, AND THE USE THEREOF

The present invention relates to an epidithiodioxopiperazine derivative represented by the Chemical Formula 1 or its reduced derivative; a method for preparing a compound represented by Chemical Formula 1 having improved intracellular permeability and mim

Monosubstitution of Symmetric Piperazine-2,5-dione Derivatives

Bromination and methanolysis of derivatives of glycine anhydride affords the corresponding 3-bromo- and 3-methoxy-substituted piperazine-2,5-dione derivatives in a simple one-pot procedure.

Divergent, Generalized Synthesis of Unsymmetrically Substituted 2,5-Piperasinediones

N,N'-Disubstituted 2,5-piperazinediones (12) can be 3,6-dibrominated followed by displacement with sodium 2-mercaptopyridine to furnish syn-1,4-disubstituted 3,6-bis(2'-thiopyridyl)-2,5-piperazinediones (8) in high yield.Precomplexation of these sulfides with silver(I) triflate followed by addition of trimethylsilyl enol ethers leads to chemoselective C-C bond formation, furnishing the homologated piperazinediones 10.The remaining sulfide functionality of 10 is relatively inert to a second substitution.These electrophylic 2,5-piperazinediones provide access to relatively inaccessible, unsymmetrical 2,5-piperazinediones and provide advantages over the corresponding well-known enolate anion approach.Substrates that contain N-p-methoxybenzyl residues can be deprotected to the lipophobic N,N'-unsubstituted 2,5-piperazinediones with aqueous ceric ammonium nitrate.The diastereoselectivity observed in the coupling reactions is discussed in the context of a single crystal X-ray structure determination of 20.