921-48-2

Basic information

• Product Name: S-2-Chloro-3-methylvaleric acid
• Synonyms: Valericacid, 2-chloro-3-methyl- (7CI,8CI); 2-Chloro-3-methylpentanoic acid;2-Chloro-3-methylvaleric acid
• CAS NO: 921-48-2
• Molecular Formula: C₆H₁₁ClO₂
• Molecular Weight: 150.6
• Mol File: 921-48-2.mol
• Article Data: 18

Chemical Properties

• Appearance: /
• CAS DataBase Reference: S-2-Chloro-3-methylvaleric acid(CAS DataBase Reference)
• NIST Chemistry Reference: S-2-Chloro-3-methylvaleric acid(921-48-2)
• EPA Substance Registry System: S-2-Chloro-3-methylvaleric acid(921-48-2)

Safety Data

• Hazardous Substances Data: 921-48-2(Hazardous Substances Data)

Usage

General Description

S-2-Chloro-3-methylvaleric acid, also known as 2-chloro-3-methylpentanoic acid, is a chemical compound with the molecular formula C6H11ClO2. It is a colorless to pale yellow liquid with a strong, pungent odor. S-2-Chloro-3-methylvaleric acid is used in the synthesis of pharmaceuticals, agrochemicals, and fragrances. It is also used as an intermediate in the production of organic compounds. S-2-Chloro-3-methylvaleric acid is classified as a hazardous substance and should be handled with caution due to its potential to cause skin and eye irritation, as well as respiratory and digestive tract irritation if inhaled or ingested.

Upstream product

• 73-32-5 L-isoleucine 
• 73-32-5 L-isoleucine 
• 4372-15-0 sec-butyl-malonic acid 
• 319-78-8 isoleucine 

Downstream Products

• 516479-93-9 4-[⁽¹⁾-chloro-⁽²⁾-methylbutyl carboxy]-4'-biphenylcarboxyphenylferrocene 
• 143238-71-5 2'-<6'-((2''S,3''S-2''-chloro-3''-methylpentanoyl)oxy)>naphthyl 4-decyloxybenzoate 
• 228267-65-0 (4R,2'S,3'S)-3-(2'-ethyl-3'-methyl-1'-oxopentyl)-4-benzyl-2-oxazolidinone 
• 210537-40-9 (4S,2'S,3'S)-3-(2'-ethyl-3'-methyl-1'-oxopentyl)-4-benzyl-2-oxazolidinone 
• 228267-64-9 (4R,3'S)-3-(3'-methyl-1'-oxopentyl)-4-benzyl-2-oxazolidinone 
• 133729-84-7 (4S,3'S)-3-(3'-methyl-1'-oxopentyl)-4-benzyl-2-oxazolidinone 
• 1730-92-3 (3S)-methylvaleric acid 
• 5026-95-9 (+)-(S)-3-methyl-1-pentene 

Relevant articles and documents

Forming Stereogenic Centers in Acyclic Systems from Alkynes

The combined carbometalation/zinc homologation followed by reactions with α-heterosubstituted aldehydes and imines proceed through a chair-like transition structure with the substituent of the incoming aldehyde residue preferentially occupying a pseudo-axial position to avoid the two gauche interactions. The heteroatom in the axial position produces a chelated intermediate (and not a Cornforth-Evans transition structure for α-chloro aldehydes and imines) leading to a face differentiation in the allylation reaction. This method provides access to functionalized products in which three new carbon-carbon bonds and two to three stereogenic centers, including a quaternary one, were created in acyclic systems in a single-pot operation from simple alkynes. All-carbon quaternary stereocenter: The combined carbometalation/zinc homologation of alkynes followed by reactions with α-heterosubstituted aldehydes and imines provides access to functionalized acyclic adducts. These adducts obtained in a single-pot reaction have three new carbon-carbon bonds and two to three stereogenic centers, including a quaternary carbon stereocenter.

Stereoselective synthesis of chiral 4-(1-Chloroalkyl)-β-lactams starting from amino acids and their transformation into functionalized chiral azetidines and pyrrolidines

Chiral short-chain α-chloroaldehydes were prepared starting from enantiomerically pure amino acids in a three-step approach, thus providing a practical synthetic alternative for known organocatalytic α-chlorination procedures. The latter aldehydes proved

Design of siloxane liquid crystals forming a de vries SmA* phase

We designed and synthesized new SmA* liquid crystals with different molecular architectures based on the chiral mesogen MR11, which was unsubstituted, or attached at one end and at both ends of a trisiloxane segment in the monosubstituted MSi3-MR11 and disubstituted DSi3-MR11 siloxanes, respectively. We studied the critical divergence of the magnetic susceptibility by measurements of the induced tilt angle θind at the SmA*-SmC* transition. While all three SmA* liquid crystals presented a de Vries character, this was quite distinctive for DSi3-MR11 for which the critical exponent γ = 1.87 was maximal. X-ray diffraction experiments confirmed that the SmA*-SmC* transition occurred with essentially no layer shrinkage.