92123-07-4

Upstream product

• 92123-06-3 Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-(6-methoxy-2-phenylsulfanyl-purin-9-yl)-tetrahydro-furan-3-yl ester 
• 16321-99-6 2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-β-D-ribofuranosyl)purine 
• 92123-05-2 6-chloro-2-phenylthio-9-(2',3',5'-tri-O-acetyl-β-D-ribofuranosyl)-9H-purine 
• 882-33-7 diphenyldisulfane 

Relevant academic research and scientific papers

CONVERSION OF GUANOSINE INTO 2-AMINOMETHYLINOSINE (2-HOMOGUANOSINE)

2-Aminomethylinosine (1), a one-carbon extended homolog of an exocyclic amino group of guanosine, was synthesized from guanosine by the use of a newly developed protection and deprotection method.Introduction of a methoxy group into the 6-position of 2-benzenesulfonyl-purine riboside facilitated a nucleophilic substitution with cyanide to afford 2-cyano-6-methoxypurine riboside (11) which was subsequently hydrogenated and demethylated with trimethylsilyl iodide to afford 1.KEYWORDS - 2-substituted purine nucleoside ; 2-homoguanosine; guanosine; cyanation; benzenesulfonyl group; trimethylsilyl iodide; demethylation; non-aqueous diazotization