92123-06-3Relevant academic research and scientific papers
CONVERSION OF GUANOSINE INTO 2-AMINOMETHYLINOSINE (2-HOMOGUANOSINE)
Matsuda, Akira,Satoh, Kazue,Miyasaka, Tadashi,Ueda, Tohru
, p. 2048 - 2051 (2007/10/02)
2-Aminomethylinosine (1), a one-carbon extended homolog of an exocyclic amino group of guanosine, was synthesized from guanosine by the use of a newly developed protection and deprotection method.Introduction of a methoxy group into the 6-position of 2-benzenesulfonyl-purine riboside facilitated a nucleophilic substitution with cyanide to afford 2-cyano-6-methoxypurine riboside (11) which was subsequently hydrogenated and demethylated with trimethylsilyl iodide to afford 1.KEYWORDS - 2-substituted purine nucleoside ; 2-homoguanosine; guanosine; cyanation; benzenesulfonyl group; trimethylsilyl iodide; demethylation; non-aqueous diazotization
