92136-43-1

Usage

Uses

Used in Chemical Synthesis:
Carbamic acid, 2,3-butadienyl-, 1,1-dimethylethyl ester (9CI) is used as a reagent in chemical synthesis for its ability to participate in various organic reactions, contributing to the formation of a wide range of chemical products.
Used in Organic Chemistry:
In the realm of organic chemistry, Carbamic acid, 2,3-butadienyl-, 1,1-dimethylethyl ester (9CI) is employed as a reagent, facilitating specific reactions that are essential for the development of new organic compounds and materials.
Used in Pesticide Production:
Carbamic acid, 2,3-butadienyl-, 1,1-dimethylethyl ester (9CI) is utilized as an intermediate in the production of pesticides, playing a crucial role in the synthesis of active ingredients that help control, repel, or kill pests.
Used in Pharmaceutical Manufacturing:
Carbamic acid, 2,3-butadienyl-, 1,1-dimethylethyl ester (9CI) also serves as an intermediate in the manufacturing of pharmaceuticals, where it is involved in the synthesis of drug molecules that address various medical needs.
Safety Precautions:
It is imperative to handle Carbamic acid, 2,3-butadienyl-, 1,1-dimethylethyl ester (9CI) with care due to its flammable nature and potential to cause skin and eye irritation upon contact. Moreover, inhalation or ingestion of Carbamic acid, 2,3-butadienyl-, 1,1-dimethylethyl ester (9CI) may lead to harmful health effects, necessitating the implementation of proper safety measures during its use in laboratories and industrial settings.

Upstream product

• 50-00-0 formaldehyd 
• 92136-39-5 N-tert-Butoxycarbonyl-1-amino-3-propyne 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2450-71-7 Propargylamine 
• 123-91-1 1,4-dioxane 
• 60-29-7 diethyl ether 

Relevant academic research and scientific papers

Aryne-mediated [2,3]-sigmatropic rearrangement of tertiary 2,3-allenylamines bearing an electron-withdrawing group at the α-position

An unprecedented [2,3]-sigmatropic rearrangement reaction of quaternary 2,3-allenylammonium ylides, generatedin situfrom tertiary 2,3-allenylamines and arynes, has been established. With 2-(trimethylsilyl)aryl triflates as aryne precursors, a range of tertiary 2,3-allenylamines bearing an electron-withdrawing group at the α-position smoothly participated in the aryne-mediated [2,3]-sigmatropic rearrangement at room temperature, delivering structurally diverse 2-vinylallyamines or 1-amino-1,3-dienes in moderate to excellent yields. The reaction proceeds in the absence of strong bases and transition metals, is compatible with moisture and air, and tolerates a wide variety of functional groups.

Selective inhibition of bovine plasma amine oxidase by homopropargylamine, a new inactivator motif

Propargylic and activated allylic amines are known to inactivate the quinone-dependent plasma amine oxidases, possibly through active-site modification by the α,β-unsaturated aldehyde turnover products. Although homopropargylamine (1-amino-3-butyne, 1) is a nonobvious candidate as a mechanism-based inhibitor, 1 was found to be an unusually potent time- and concentration-dependent irreversible inactivator of bovine plasma amine oxidase (BPAO), exhibiting a 30 min IC50 of 2.9 μM at 30 °C ([BPAO] = 1.2 μM). Preserved cofactor redox activity of the denatured inactivated enzyme indicates that inactivation by 1 involves either a cofactor modification that reverses upon enzyme denaturation or a modification of an active-site residue. Because inactivation by 1 may involve enzyme alkylation by the reactive 2,3-butadienal (3) tautomer of the 3-butynal turnover product of 1, aldehyde 3 was prepared and was found to inactivate BPAO, but only at high concentration. In addition, whereas inhibition by 3 was blunted by the presence of mercaptoethanol, no such protection was observed against 1. The amine whose turnover should lead directly to 3 was prepared (1-amino-2,3-butadiene, 4) and was found to be an even more potent inactivator of BPAO than 1, exhibiting a 5 min IC50 of 1.25 μM. Rat liver mitochondrial monoamine oxidase was also inactivated by 4, as expected, but only very weakly by 1. Potential mechanisms explaining the selective inhibition of BPAO by 1 are discussed.

Method of potentiating cell-mediated immunity utilizing polyamine derivatives

This invention relates to a method of potentiating cell-mediated immunity which comprises administering to a patient a cell-mediated immunity potentiating amount of a compound of the formula: or a pharmaceutically acceptable salt thereof, wherein m is

GENERAL SYNTHETIC ACCESS TO α-ALLENYL AMINES AND α-ALLENYL-α-AMINOACIDS AS POTENTIAL ENZYME ACTIVATED IRREVERSIBLE INHIBITORS OF PLP DEPENDENT ENZYMES

The entitled allene derivatives have been prepared from the parent α-ethynyl amines and α-amino acids.The corresponding derivative of GABA, putrescine and phenylalanine have been found to be irreversible and time dependent inhibitors of GABA-T, ODC and ba