92144-20-2 Usage
Uses
Used in Pharmaceutical Research:
2,4-diamino-5-chloro-N,N-dimethylquinazoline-6-sulfonamide is used as a potential antitumor agent for its ability to inhibit the growth of cancer cells. Its unique chemical structure, featuring a quinazoline ring and a sulfonamide group, contributes to its biological activity and makes it a promising candidate for further research and development in oncology.
Used in Cancer Treatment:
In the field of oncology, 2,4-diamino-5-chloro-N,N-dimethylquinazoline-6-sulfonamide is being investigated for its potential use as a therapeutic agent in treating various types of cancer. Its anti-cancer properties have shown promising results in preclinical studies, warranting further exploration of its efficacy and safety in clinical settings.
Used in Drug Development:
2,4-diamino-5-chloro-N,N-dimethylquinazoline-6-sulfonamide is also being considered for its potential application in the development of new drugs for the treatment of other diseases, beyond cancer. Its biological activity and unique chemical structure make it a valuable compound for exploring novel therapeutic approaches and targeting specific disease pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 92144-20-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,1,4 and 4 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 92144-20:
(7*9)+(6*2)+(5*1)+(4*4)+(3*4)+(2*2)+(1*0)=112
112 % 10 = 2
So 92144-20-2 is a valid CAS Registry Number.
92144-20-2Relevant academic research and scientific papers
Folate antagonists. 22. Antimalarial and antibacterial effects of 2,4-diamino-6-quinazolinesulfonamides
Elslager,Colbry,Davoll,Hutt,Johnson,Werbel
, p. 1740 - 1743 (2007/10/02)
The synthesis and antimalarial activity of a series of 2,4-diamino-6-quinazolinesulfonamides is described. Chlorosulfonation of 2,4-quinazolinediamine affords the 6-sulfonyl chloride, which upon treatment with the appropriate amine produces the desired products. Alternatively the sulfonyl chloride could be introduced by diazotization of the corresponding amine followed by treatment with SO2 in the presence of CuCl2. Although substantial antimalarial activity was demonstrated for several members of this class, studies were discontinued in light of the potency of related series.
