92144-21-3 Usage
Uses
Used in Pharmaceutical Industry:
2,4-diamino-5-chloro-N,N-diethylquinazoline-6-sulfonamide is used as an antibiotic for the treatment of urinary tract infections. It is effective against susceptible bacteria due to its ability to inhibit folic acid synthesis, which is essential for bacterial growth and survival. 2,4-diamino-5-chloro-N,N-diethylquinazoline-6-sulfonamide is typically administered orally and is well-absorbed into the bloodstream, allowing for effective treatment of infections.
Check Digit Verification of cas no
The CAS Registry Mumber 92144-21-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,2,1,4 and 4 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 92144-21:
(7*9)+(6*2)+(5*1)+(4*4)+(3*4)+(2*2)+(1*1)=113
113 % 10 = 3
So 92144-21-3 is a valid CAS Registry Number.
92144-21-3Relevant academic research and scientific papers
Folate antagonists. 22. Antimalarial and antibacterial effects of 2,4-diamino-6-quinazolinesulfonamides
Elslager,Colbry,Davoll,Hutt,Johnson,Werbel
, p. 1740 - 1743 (2007/10/02)
The synthesis and antimalarial activity of a series of 2,4-diamino-6-quinazolinesulfonamides is described. Chlorosulfonation of 2,4-quinazolinediamine affords the 6-sulfonyl chloride, which upon treatment with the appropriate amine produces the desired products. Alternatively the sulfonyl chloride could be introduced by diazotization of the corresponding amine followed by treatment with SO2 in the presence of CuCl2. Although substantial antimalarial activity was demonstrated for several members of this class, studies were discontinued in light of the potency of related series.
