921447-59-8

Upstream product

• 106-47-8 4-chloro-aniline 
• 762-42-5 dimethyl acetylenedicarboxylate 
• 74-89-5 methylamine 
• 87748-34-3 C₁₂H₁₂ClNO₄ 

Downstream Products

• 1613024-49-9 3-benzyl-1-(4-chlorophenyl)-6-methyl-1,2,3,4-tetrahydro-6H-pyrrolo[3,4-d]pyrimidine-5,7-dione 
• 1613024-50-2 1-(4-chlorophenyl)-3-cyclohexyl-6-methyl-1,2,3,4-tetrahydro-6H-pyrrolo[3,4-d]pyrimidine-5,7-dione 

Relevant academic research and scientific papers

An Efficient Synthesis of Spiropyrroloquinolines by the Domino Reaction of α-Dicarbonyl Compounds and Anilinosuccinimides

A domino annulation reaction of various α-dicarbonyl compounds with anilinosuccinimides takes place with Br?nsted-acid catalysis under microwave irradiation to give functionalized spiropyrroloquinolines. The reaction involves activation of the ortho hydrogen of the different aniline derivatives.

Synthesis of fused pyrrolo[3,4-d]tetrahydropyrimidine derivatives by proline-catalyzed multicomponent reaction

Novel proline-catalyzed multicomponent reactions (MCRs) for the synthesis of fused pyrrolo[3,4-d]tetrahydropyrimidines 7 and 9 with different substituted patterns have been developed, which provide rapid access to a library of compounds 7 and 9 in medium to excellent yields, by using N-methyl-α- aryl(alkyl)aminomaleimides, amines, and aldehydes as reactants. The catalyst and the ratio of reactants were found to have significant impact on these reactions, and a reasonable mechanism was also proposed.