92152-08-4

Basic information

• Product Name: 1,6-difuryl-1,5-hexadiene-3,4-dione
• Synonyms: 1,6-difuryl-1,5-hexadiene-3,4-dione
• CAS NO: 92152-08-4
• Molecular Formula: C14H10O4
• Molecular Weight: 242
• Mol File: 92152-08-4.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 381.6°C at 760 mmHg
• Flash Point: 181.8°C
• Appearance: /
• Density: 1.26g/cm³
• Vapor Pressure: 5.01E-06mmHg at 25°C
• Refractive Index: 1.613
• CAS DataBase Reference: 1,6-difuryl-1,5-hexadiene-3,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 1,6-difuryl-1,5-hexadiene-3,4-dione(92152-08-4)
• EPA Substance Registry System: 1,6-difuryl-1,5-hexadiene-3,4-dione(92152-08-4)

Safety Data

• Hazardous Substances Data: 92152-08-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H10O4/c15-13(7-5-11-3-1-9-17-11)14(16)8-6-12-4-2-10-18-12/h1-10H

Upstream product

• 98-01-1 furfural 
• 431-03-8 dimethylglyoxal 

Downstream Products

• 1190209-39-2 4,4'-di(2-furyl)-6,6'-diphenyl-2,2'-bipyridine 
• 144342-48-3 4,4'-Bis(fur-2-yl)-6,6'-dimethyl-2,2'-bipyridine 
• 117330-41-3 4,4'-dimethyl 6,6'-bis(bromomethyl)-[2,2'-bipyridine]-4,4'-dicarboxylate 
• 144342-49-4 6,6′-dimethyl-2,2′-bipyridine-4,4′-dicarboxylic acid 
• 117330-40-2 dimethyl 6,6'-dimethyl-2,2'-bipyridine-4,4'-dicarboxylate 

Relevant articles and documents

Synthesis of cinnamils and quinoxalines and their biological evaluation as anticancer agents

We synthesized multiple cinnamils and quinoxalines to evaluate their anticancer activity. Cinnamils were used as precursors for quinoxalines via condensation with 1,2-diaminobenzene. Among the 26 synthesized compounds reported in this article, we found that cinnamil 3l exhibited its inhibitory effect with an IC50 value of 1.45 ± 0.98 μM, significantly higher than doxorubicin (8.5 ± 0.85 μM) against pancreatic cancer cells (PANC-1). Additionally, cinnamil 3l (IC50 10.98 ± 3.63 μM) showed less cytotoxicity than doxorubicin to Hs68 cells (0.92 ± 1.11 μM). The colony formation assay demonstrated that 3l obviously decreased the PANC-1 cell viability, and Western blot assays confirmed that 3l markedly induced apoptosis of PANC-1 cells through Bax, Bcl-2, and caspase 3 signaling cascades. These results demonstrate that cinnamil 3l has great potential to be further developed as a promising chemotherapeutic agent for pancreatic cancer.

Preparation of cycloheptane ring by nucleophilic cyclopropanation of 1,2-diketones with bis(iodozincio)methane

The nucleophilic cyclopropanation of hexa-1,5-diene-3,4-diones with bis(iodozincio)methane afforded the Zn alkoxides of cis-dialkenylcyclopropane-1,2-diols stereoselectively. The subsequent oxy-Cope rearrangement afforded the corresponding Zn alkoxides of

Preparation of a cycloheptane ring from a 1,2-diketone with high stereoselectivity

Treatment of 1,6-dialkylhexa-1,5-diene-3,4-diones with bis(iodozincio) methane gave zinc alkoxides of cis-5,6-dialkylcyclohepta-3,7-diene-1,3-diol in good yields at room temperature. The reaction proceeded with high stereospecificity. Bis(iodozincio)metha