92156-72-4

Basic information

• Product Name: 6-PHENOXY-HEXANOIC ACID METHYL ESTER
• Synonyms: 6-PHENOXY-HEXANOIC ACID METHYL ESTER;Methyl 6-phenoxyhexanoate
• CAS NO: 92156-72-4
• Molecular Formula: C₁₃H₁₈O₃
• Molecular Weight: 222.28022
• Mol File: 92156-72-4.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-PHENOXY-HEXANOIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 6-PHENOXY-HEXANOIC ACID METHYL ESTER(92156-72-4)
• EPA Substance Registry System: 6-PHENOXY-HEXANOIC ACID METHYL ESTER(92156-72-4)

Safety Data

• Hazardous Substances Data: 92156-72-4(Hazardous Substances Data)

Upstream product

• 588-63-6 3-phenoxypropyl bromide 
• 292638-85-8 acrylic acid methyl ester 
• 66800-56-4 N-methoxycarbonyl-6-aminohexanoic acid 
• 14273-90-6 methyl 6-bromohexanoate 
• 108-95-2 phenol 
• 70288-80-1 6-methoxycarbonylaminohexanoic acid methyl ester 

Downstream Products

• 89709-69-3 6-Phenoxy-hexanoic acid (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-dimethyl-hexyl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 

Relevant articles and documents

Cobalt-catalyzed reductive coupling of saturated alkyl halides with activated alkenes

An efficient cobalt-catalyzed reductive coupling reaction of alkyl halides with electron-withdrawing alkenes (CH2=CR1EWG, EWG = electron-withdrawing group) in the presence of water and zinc powder in acetonitrile to give the corresponding Michael-type addition product (RCH 2CR1EWG) was described. The methodology is versatile such that unactivated primary, secondary, and tertiary alkyl bromides and iodides and various conjugated alkenes including acrylates, acrylonitrile, methyl vinyl ketone, and vinyl sulfone all successfully participate in this coupling reaction. For the alkyl halides used in the reaction, the iodides generally gave heller yields compared to those of the corresponding bromides. It is a unique method employing CoI2dppe, zinc, and alkyl halides, affording conjugate addition products in high yields. Mechanistically, the reaction appears to follow an oxidative addition driven route rather than the previously reported radical route.