921604-25-3

Upstream product

• 42142-15-4 1-(4-nitro-phenyl)-ethylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 172153-32-1 tert-butyl (1-(4-nitrophenyl)ethyl)carbamate 
• 643086-68-4 [1-(4-amino-phenyl)-ethyl]carbamic acid tert-butyl ester 
• 108-24-7 acetic anhydride 

Downstream Products

• 757151-43-2 N-(4-(1-aminoethyl)phenyl)acetamide 

Relevant academic research and scientific papers

4-Aminopyrimidines as novel HIV-1 inhibitors

A series of 4-aminopyrimidines (1) was identified as novel HIV inhibitors of unknown molecular target. Structural modifications were carried out to establish its SAR and identify the linking site for target identification. A number of analogs were found to possess single digit inhibitory activity for HIV replication. Several analogs with various potential linkers, including a biotinated analog, also exhibited excellent potency, and could serve as tools for the identification of novel anti-HIV targets.

Azetidine, pyrrolidine and piperidine derivatives

A class of substituted azetidine, pyrrolidine and piperidine derivatives are selective agonists of 5-HT1 -like receptors, being potent agonists of the human 5-HT1Dα receptor subtype whilst possessing at least a 10-fold selective affinity for the 5-HT1Dα receptor subtype relative to the 5-HT1Dβ subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT1D receptors is indicated, whilst eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT1D receptor agonists.