757151-43-2

Upstream product

• 120342-68-9 methyl N-(4-(1-azidoethyl)phenyl)acetamide 
• 42142-15-4 1-(4-nitro-phenyl)-ethylamine 
• 3663-34-1 N-(4-ethylphenyl)acetamide 
• 2719-21-3 4-(N-acetylamino)acetophenone 
• 172153-32-1 tert-butyl (1-(4-nitrophenyl)ethyl)carbamate 
• 643086-68-4 [1-(4-amino-phenyl)-ethyl]carbamic acid tert-butyl ester 
• 921604-25-3 N-tert-Butyloxycarbonyl-(S)-1-(4-acetamidophenyl)ethylamine 

Downstream Products

• 120342-71-4 N-[4-(1-Amino-ethyl)-phenyl]-acetamide; hydrochloride 

Relevant academic research and scientific papers

Air Stable Iridium Catalysts for Direct Reductive Amination of Ketones

Half-sandwich iridium complexes bearing bidentate urea-phosphorus ligands were found to catalyze the direct reductive amination of aromatic and aliphatic ketones under mild conditions at 0.5 mol % loading with high selectivity towards primary amines. One of the complexes was found to be active in both the Leuckart–Wallach (NH4CO2H) type reaction as well as in the hydrogenative (H2/NH4AcO) reductive amination. The protocol with ammonium formate does not require an inert atmosphere, dry solvents, as well as additives and in contrast to previous reports takes place in hexafluoroisopropanol (HFIP) instead of methanol. Applying NH4CO2D or D2 resulted in a high degree of deuterium incorporation into the primary amine α-position.

4-Aminopyrimidines as novel HIV-1 inhibitors

A series of 4-aminopyrimidines (1) was identified as novel HIV inhibitors of unknown molecular target. Structural modifications were carried out to establish its SAR and identify the linking site for target identification. A number of analogs were found to possess single digit inhibitory activity for HIV replication. Several analogs with various potential linkers, including a biotinated analog, also exhibited excellent potency, and could serve as tools for the identification of novel anti-HIV targets.

Selective Conversion of Benzylic C-H Bonds to an Amine Function by Oxidative Nucleophilic Substitution

The benzylic proton of alkylarenes 1 was replaced by an azido group in one step by reaction with trimethylsilyl azide or hydrazoic acid in chloroform in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ).The 1-arylalkyl azides 2 were reduced to amines 3, which were characterized as their hydrochlorides 4.