921622-74-4Relevant academic research and scientific papers
Metal-Free Cascade Annulation Approach for Modular Assembly of Alkynyl/Benzoyl Functionalized Quinolines
Tang, Qiang,Yuan, Meng,Duan, Jiahui,Xu, Keke,Li, Ruxue,Xie, Mengqing,Kong, Shuwen,He, Xinwei,Shang, Yongjia
supporting information, (2022/01/19)
A concise and efficient synthetic method for alkynyl quinolines through TfOH-promoted cascade 1,4-conjugate addition/intramolecular annulation/aromatization process is established. By virtue of reactive aza-o-AQM (in situ generated from modular propargylamine), this reaction proceeds smoothly to afford a variety of alkynyl quinolines in good to excellent yields. This transition-metal-free process features halogen groups tolerance, such as the ?Cl, ?Br, and ?I groups; thus, this protocol circumvents the inherent shortcomings of the existing Sonogashira coupling of halogenated quinolines.
Β-carbonyl enamines compound and as the application of the preparation of plant pathogenic bacteria antibacterial agent (by machine translation)
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Paragraph 0055-0062; 0069; 0070, (2016/10/08)
The invention relates to a β-carbonyl compound and enamines preparation of plant pathogenic bacteria as the application of an antimicrobial agent. Commercially available antibacterial agent Mijunzhi as a positive control, the linear growth of the mycelium determination process 23 kind of target compound anthrax pathogenicbacteria the apple, corn curved spore pathogenic bacterium, pathogenic bacteria rice blast fungus, reducing bakanae disease of wheat, such as watermelon blighting pathogenicbacteria 5 common inhibiting activity of plant pathogenic fungi, the result shows that: the target compound has tries the fungus inhibiting effect of different degree. Compound 8, 11, 12, 14, 16 of the activity is better, for the majority of their pathogenic bacteria testing EC 50 half of the effect of the concentration value is higher than the positive control drug kresoxim-methyl. Especially compound 8 inhibition of anthrax pathogenicbacteria the apple active (EC 50 = 2.15μg/mL) compound and 12 the inhibitory activity of pathogenic bacterium curved spore (EC 50 = 9.14μg/mL) are Mijunzhi active (EC 50 = 15.45 & 76.06μg/mL) of 8 times, has potential development and application values. (by machine translation)
4-Chromenonyl-1,4-dihydropyridines and their use
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Page/Page column 33, (2010/02/17)
The present application relates to novel 4-chromenonyl-1,4-dihydropyridines, process for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis o
