92173-87-0Relevant academic research and scientific papers
Synthesis of substituted benzenes from α-methylene ketones
Khaidem, Ibomacha Singh,Singh, Sagolsem Lokhol,Singh, Laishram Ramananda,Khan, Mohd Ziaur Rahman
, p. 911 - 914 (2007/10/03)
A new general method for the synthesis of substituted benzenes from cyclic ketones having active methylene groups via the corresponding hydroxymethylene ketones and enamino-ketones has been developed. Formylation of these ketones with ethyl formate followed by enamination with pyrrolidine produces enamino-ketones which on reaction with threefold excess of malononitrile in boiling benzene in the presence of ammonium acetate in acetic acid gives the substituted benzenes in good yield. The reaction has been extended to aliphatic and aromatic ketones having active methylene groups to give substituted benzenes and biphenyls, respectively.
The Preparation and the Nucleophilic Reaction of 3,3-Di(1-azolyl)-2-alken-1-ones, Precursor of Acetylketene Derivatives
Kashima, Choji,Tajima, Tadakuni,Omote, Yoshimori
, p. 133 - 138 (2007/10/02)
2-Alken-1-ones, 3,3-di-(1-azolyl)-2-alken-1-ones and related compounds were prepared by two methods.These compounds were found to be the useful precursors for acylketene derivatives such as ketene dithioacetals and diaminals by treatment with various nucleophiles.
Reactivities of 3-(1-Azolyl)-2-alken-1-ones and the Related Compounds With Pyrrolidine
Kashima, Choji,Tajima, Tadakuni,Higuchi, Chihiro,Omote, Yoshimori
, p. 345 - 348 (2007/10/02)
From the rate constants of the reaction with pyrrolidine, the reactivities of 3-(1-azolyl)-2-alken-1-ones with nucleophiles were evaluated to be rather high.Especially the reactivities of the quarternary salts of 3-(1-imidazolyl)-2-alken-1-ones were nearly equal to those of 3-chloro-2-alken-1-ones.In conclusion, 3-(1-imidazolyl)-2-alken-1-ones satisfied the practical requirements for the starting materials of the synthesis of 3-hetero-substituted 2-alken-1-ones.
