92206-72-9

Basic information

• Product Name: 4-BROMOBENZYLMAGNESIUM BROMIDE
• Synonyms: 4-BROMOBENZYLMAGNESIUM BROMIDE;4-BroMobenzylMagnesiuM broMide, 0.25M in 2-MeTHF;4-BroMobenzylMagnesiuM broMide, 0.25M in diethyl ether
• CAS NO: 92206-72-9
• Molecular Formula: C₇H₆Br₂Mg
• Molecular Weight: 274.24
• Mol File: 92206-72-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 34.6℃
• Flash Point: -45°(-49°F)
• Appearance: /
• Water Solubility: Insoluble in water.
• Sensitive: Air & Moisture Sensitive
• CAS DataBase Reference: 4-BROMOBENZYLMAGNESIUM BROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMOBENZYLMAGNESIUM BROMIDE(92206-72-9)
• EPA Substance Registry System: 4-BROMOBENZYLMAGNESIUM BROMIDE(92206-72-9)

Safety Data

• HazardClass: 3
• Hazardous Substances Data: 92206-72-9(Hazardous Substances Data)

Usage

General Description

4-Bromobenzylmagnesium bromide is a chemical compound with the formula C7H6Br2Mg. It is an organometallic reagent widely used in organic synthesis as a source of the benzyl group. 4-BROMOBENZYLMAGNESIUM BROMIDE is commonly employed in the Grignard reaction, where it can undergo nucleophilic substitution reactions with a variety of electrophiles to form new carbon-carbon bonds. It is a valuable tool in the synthesis of pharmaceuticals and fine chemicals, and its high reactivity and selectivity make it a versatile reagent in organic chemistry. The compound is typically prepared in situ by the reaction of 4-bromobenzyl chloride with magnesium in anhydrous diethyl ether.

InChI:InChI=1/C7H6Br.BrH.Mg/c1-6-2-4-7(8)5-3-6;;/h2-5H,1H2;1H;/q;;+1/p-1/rC7H6Br2Mg/c8-7-3-1-6(2-4-7)5-10-9/h1-4H,5H2

Upstream product

• 589-15-1 1-bromomethyl-4-bromobenzene 

Downstream Products

• 859777-18-7 2-(4-bromo-phenyl)-1,1-diphenyl-ethanol 
• 114303-26-3 2-(4-bromo-phenyl)-1-(2-chloro-phenyl)-1-(4-chloro-phenyl)-ethene 
• 1293391-61-3 3-(4-bromobenzyl)-1H-indole 
• 1190763-76-8 (4-bromophenyl)(1H-indol-3-yl)methanol 
• 1255150-16-3 C₄₀H₆₁BrN₂O₂Si₂ 
• 1255150-24-3 C₆₂H₁₀₁BrN₂O₆Si₂ 
• 569680-18-8 10-(4-Bromobenzyl)-8-chloro-10-(trifluoromethyl)-5,10-dihydropyrimido [5,4-b] quinolin-4(3H)-one 
• 103046-49-7 4-[2,2-bis(4-dimethylaminophenyl)ethenyl]benzonitrile 
• 102183-08-4 4-[2,2-bis(4-chloro-phenyl)-vinyl]benzonitrile 
• 102594-05-8 4-(2,2-di-p-tolyl-vinyl)-benzonitrile 

Relevant articles and documents

RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.