92206-72-9

Usage

Uses

Used in Organic Synthesis:
4-BROMOBENZYLMAGNESIUM BROMIDE is used as a reagent for the synthesis of pharmaceuticals and fine chemicals. Its high reactivity and selectivity make it a valuable tool in the synthesis of various organic compounds.
Used in Grignard Reactions:
In the Grignard reaction, 4-BROMOBENZYLMAGNESIUM BROMIDE is used as a nucleophile to undergo substitution reactions with a variety of electrophiles, leading to the formation of new carbon-carbon bonds. This reaction is a key method in organic chemistry for the formation of carbon-carbon bonds and the synthesis of complex organic molecules.
Used in the Preparation of 4-Bromobenzyl Compounds:
4-BROMOBENZYLMAGNESIUM BROMIDE is used as a starting material in the preparation of 4-bromobenzyl chloride, which can be further used to synthesize various 4-bromobenzyl compounds with potential applications in different industries.
Used in the Synthesis of Complex Organic Molecules:
Due to its high reactivity and selectivity, 4-BROMOBENZYLMAGNESIUM BROMIDE is used in the synthesis of complex organic molecules, including natural products, pharmaceuticals, and other fine chemicals. Its ability to form new carbon-carbon bonds makes it a crucial component in the development of novel organic compounds with potential applications in various fields.

InChI:InChI=1/C7H6Br.BrH.Mg/c1-6-2-4-7(8)5-3-6;;/h2-5H,1H2;1H;/q;;+1/p-1/rC7H6Br2Mg/c8-7-3-1-6(2-4-7)5-10-9/h1-4H,5H2

Upstream product

• 589-15-1 1-bromomethyl-4-bromobenzene 

Downstream Products

• 114303-26-3 2-(4-bromo-phenyl)-1-(2-chloro-phenyl)-1-(4-chloro-phenyl)-ethene 
• 112325-97-0 2-(4-bromo-phenyl)-1-(4-chloro-phenyl)-1-p-tolyl-ethene 
• 111561-90-1 4,4',4''-(ethene-1,1,2-triyl)tris(bromobenzene) 
• 20336-00-9 (p-Brom-benzyl)-phenyl-phosphinoxid 
• 17095-20-4 p-<(trimethylsilyl)methyl>bromobenzene 
• 111561-82-1 2-(4-bromo-phenyl)-1,1-bis-(4-chloro-phenyl)-ethene 
• 114889-49-5 4,4'-(2-(4-bromophenyl)ethene-1,1-diyl)bis(methylbenzene) 
• 859777-18-7 2-(4-bromo-phenyl)-1,1-diphenyl-ethanol 

Relevant academic research and scientific papers

RET INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Provided herein are a RET inhibitor, a pharmaceutical composition thereof and uses thereof. In particular, provided is a compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a solvate, a metabolite, a pharmaceutically acceptable salt or a prodrug thereof. Provided is a pharmaceutical composition comprising the compound, and uses of the compound and pharmaceutical composition thereof for the preparation of a medicament, in particular for treatment and prevention of RET-related diseases and conditions, including cancer, irritable bowel syndrome, and/or pain associated with irritable bowel syndrome.

Benzylic Grignard Reagents: Application of (thf = tetrahydrofuran) in Regioselective Grignard Formation and C-O Cleavage in Benzyl Ethers

Benzylic Grignard reagents (2)-(4), bearing ortho- and para-halogeno ring substituents, are readily accessible by treating the corresponding benzylic halide with (1) in tetrahydrofuran (thf); o- and p-chloromethyl(methoxymethyl)benzenes with (1) rapidly yield 'di-Grignards' whereas the meta-isomer only affords a mono-Grignard' (5), and bis(methoxymethyl)benzenes slowly undergo C-O cleavage, (6).