1293391-61-3Relevant academic research and scientific papers
Nickel-catalysed chemoselective C-3 alkylation of indoles with alcohols through a borrowing hydrogen method
Adhikari, Debashis,Bains, Amreen K.,Biswas, Ayanangshu
, p. 15442 - 15445 (2020)
An inexpensive, air-stable, isolable nickel catalyst is reported that can perform chemoselective C3-alkylation of indoles with a variety of alcohols following "borrowing hydrogen". A one-pot, cascade C3-alkylation starting from 2-aminophenyl ethyl alcohols, and thus obviating the need for pre-synthesized indoles, further adds to the broad scope of this method. The reaction is radical-mediated, and is significantly different from other examples, often dictated by metal-ligand bifunctionality. This journal is
A highly regioselective C-3 benzylation reaction of indoles with alcohols catalysed by an N-heterocyclic carbene
Zhu, Yan-Fang,Lu, Guo-Ping,Cai, Chun
, p. 438 - 441 (2015/11/03)
The direct C-3 alkylation of indoles with primary and secondary alcohols through the combination of KOH and an N-heterocyclic carbene is described. The KOH/NHC-catalysed system can give desired C-3 alkylated indoles with high selectivity in moderate to excellent yields. Moreover, this process has obvious advantages such as high atom economy and the absence of a metal source.
A highly efficient route to C-3 alkyl-substituted indoles via a metal-free transfer hydrogenation
Chen, Cai,Feng, Huan-Xi,Li, Zhi-Long,Cai, Pin-Wen,Liu, Yan-Kai,Shan, Lian-Hai,Zhou, Xian-Li
supporting information, p. 3774 - 3776 (2014/07/07)
A highly efficient route to C-3 alkyl-substituted indoles via completely metal-free catalytic transfer hydrogenation of 3-indolemethanols was developed. This process proceeds via vinylogous iminium intermediates formed in situ in the presence of Br?nsted
An efficient one-pot synthesis of 2-benzylpyrroles and 3-benzylindoles
Sharma, Ratnesh,Chouhan, Mangilal,Sood, Divya,Nair, Vipin A.
experimental part, p. 305 - 309 (2012/01/03)
One-pot regioselective benzylation of pyrroles and indoles using zirconium tetrachloride is discussed. This has been achieved by in-situ generation of di(1H-pyrrol-1-yl)zirconium(IV) chloride and di(1H-indol-1-yl)zirconium(IV) chloride. It was observed th
