92208-94-1

Basic information

• Product Name: (2S,4S,5R)-2,3,4-Trimethyl-5-phenyl-1,3,2-oxazaphospholidin
• CAS NO: 92208-94-1
• Molecular Weight: 209.228
• Mol File: 92208-94-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,4S,5R)-2,3,4-Trimethyl-5-phenyl-1,3,2-oxazaphospholidin(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4S,5R)-2,3,4-Trimethyl-5-phenyl-1,3,2-oxazaphospholidin(92208-94-1)
• EPA Substance Registry System: (2S,4S,5R)-2,3,4-Trimethyl-5-phenyl-1,3,2-oxazaphospholidin(92208-94-1)

Safety Data

• Hazardous Substances Data: 92208-94-1(Hazardous Substances Data)

Upstream product

• 14937-39-4 methyl-bis(dimethylamino)phosphine 
• 299-42-3 ephedrine 

Relevant articles and documents

Asymmetric Synthesis of 2-Organo-1,3,2-oxazaphospholidines

Achiral organophosphonous diamides RP(NMe2)2 react with chiral amino alcohols such as L-ephedrine and L-prolinol to form methyl- and phenyl-substituted mono- (2,3) and bicyclic 1,3,2-oxazaphospholidines (6-8) in good yields.Organophosphonous dichloride allow the synthesis of oxazaphospholidines only for R = tert-butyl (4,5).The diastereomeric excess of the ephedrine and prolinol derivatives ranges from 80percent (R = methyl) to 95percent d.e. (R = tert-butyl).The bis-1,3,2-oxazaphospholidine 8, made from two mols of prolinol and one mol of 1,2-ethanediylbis, is virtually diastereomerically pure according to the NMR spectrum.Analysis of the 13C-31P and 1H-31P coupling constants afford the structural assignment of the ephedrine derivatives as (2S,4S,5R) and the prolinol derivatives as (2R,5S).