92210-59-8

Basic information

• Product Name: 8-METHOXY-3-NITRO-2H-CHROMENE)
• Synonyms: 8-METHOXY-3-NITRO-2H-CHROMENE)
• CAS NO: 92210-59-8
• Molecular Formula: C₁₀H₉NO₄
• Molecular Weight: 207.18276
• Mol File: 92210-59-8.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 349°C at 760 mmHg
• Flash Point: 168.9°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 9.74E-05mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: 8-METHOXY-3-NITRO-2H-CHROMENE)(CAS DataBase Reference)
• NIST Chemistry Reference: 8-METHOXY-3-NITRO-2H-CHROMENE)(92210-59-8)
• EPA Substance Registry System: 8-METHOXY-3-NITRO-2H-CHROMENE)(92210-59-8)

Safety Data

• Hazardous Substances Data: 92210-59-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Synthetic Communications, 20, p. 783, 1990 DOI: 10.1080/00397919008052323

InChI:InChI=1/C10H9NO4/c1-14-9-4-2-3-7-5-8(11(12)13)6-15-10(7)9/h2-5H,6H2,1H3

Upstream product

• 625-48-9 2-nitro-1-ethanol 
• 148-53-8 3-methoxy-2-hydroxybenzaldehyde 
• 3638-64-0 1-nitroethylene 

Downstream Products

• 1370549-74-8 (6aS,13cR)-9-benzyl-4-methoxy-6a-nitro-6,6a,7,8,9,13c-hexahydrochromeno[3,4-c]carbazole 
• 112904-74-2 (-)-8-hydroxy-3,4-dihydro-3-(di-n-propylamino)-2H-1-benzopyran 
• 112904-74-2 (+)-8-hydroxy-3,4-dihydro-3-(di-n-propylamino)-2H-1-benzopyran 
• 112904-74-2 N,N-di-n-propyl-8-hydroxy-3-chromanamine 
• 112904-73-1 8-methoxychroman-3-amine 

Relevant articles and documents

Medicine for preventing and treating gingivitis and preparation method thereof

The invention provides 3-nitro-8-substituted-2H-benzopyran compounds, a preparation method thereof and application thereof in preparing medicines for preventing and treating gingivitis and diseases caused by bacteroides fragilis ATCC 25285 or P.copporis ATCC 33547, and belongs to the field of medicinal chemistry. A series of compounds are prepared by a chemical synthesis method, and the structureis determined by mass spectrometry and nuclear magnetic resonance spectroscopy, and bacteriostatic activity experimental researches are performed on common pathogenic bacteria of gingivitis, bacteroides fragilis ATCC 25285 or P.copporis ATCC 33547. It is found that the novel compounds are comparable to or even better than positive control ciprofloxacin in activity, and are expected to be further developed into a therapeutic drug for gingivitis.

New Direct Synthesis of 3-Nitro-2H-chromenes Using Nitroethylene

The treatment of substituted 2-hydroxybenzaldehydes by nitroethylene, prealably prepared or generated in situ within the reaction, in the presence of di-n-butylamine gave 3-nitro-2H-chromenes in fair to excellent yields.