922161-63-5

Upstream product

• 116278-66-1 N-(4-chloro-2-hydroxyphenyl)-2,2-dimethylpropanamide 
• 28443-50-7 2-amino-5-chlorophenol 
• 3282-30-2 pivaloyl chloride 
• 922162-92-3 3-(5-chloro-2-[(2,2-dimethylpropyl)amino]-3-[(S)-hydroxy-(2-methoxyphenyl)methyl]phenoxy)propan-1-ol 
• 1490-25-1 succinic acid monomethylester chloride 
• 922162-90-1 3-(5-chloro-2-[(2,2-dimethylpropyl)amino]-3-[hydroxy-(2-methoxyphenyl)methyl]phenoxy)propan-1-ol 
• 922162-89-8 N-(4-chloro-2-[hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxypropoxy)phenyl)-2,2-dimethylpropanamide 
• 922162-88-7 N-[4-chloro-2-(3-hydroxypropoxy)phenyl]-2,2-dimethylpropanamide 
• 922162-87-6 N-(2-[3-(benzyloxy)propoxy]-4-chlorophenyl)-2,2-dimethylpropanamide 

Downstream Products

• 922161-64-6 4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)-methyl]-6-(3-hydroxypropoxy)phenyl)(2,2-dimethylpropyl)-amino]-4-oxobutanoic acid 
• 1334531-23-5 ethyl (3S)-1-(4-[(4-chloro-2-[(S)-hydroxy(2-methoxyphenyl)methyl]-6-(3-hydroxypropoxy)phenyl)(2,2-dimethylpropyl)amino]-4-oxobutanoyl)piperidine-3-carboxylate 

Relevant academic research and scientific papers

Discovery of atrop fixed alkoxy-aminobenzhydrol derivatives: Novel, highly potent and orally efficacious squalene synthase inhibitors

We have recently reported the discovery of the new benzhydrol template, which has a highly potent inhibitory activity for squalene synthase, as typified by compound 1 (SSI IC50 = 0.85 nM). However, it was composed of a pair of easy rotatable at